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Gkn1 gastrokine 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297418, updated on 5-Mar-2024

Summary

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Official Symbol
Gkn1provided by RGD
Official Full Name
gastrokine 1provided by RGD
Primary source
RGD:735014
See related
Ensembl:ENSRNOG00000008838 AllianceGenome:RGD:735014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fov; Ca11; Amp18; foveolin
Summary
Predicted to enable growth factor activity. Predicted to be involved in regulation of cell population proliferation. Predicted to act upstream of or within positive regulation of cell population proliferation. Predicted to be located in secretory granule. Predicted to be active in extracellular space. Orthologous to human GKN1 (gastrokine 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 1.4), Adrenal (RPKM 1.1) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (121347417..121352705, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (119790101..119795389, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (119143070..119148358, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene glutamine fructose-6-phosphate transaminase 1 Neighboring gene ANTXR cell adhesion molecule 1 Neighboring gene uncharacterized LOC120102329 Neighboring gene gastrokine 2 Neighboring gene gastrokine 3 Neighboring gene bone morphogenetic protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gastrokine 1 is abundantly and specifically expressed in superficial gastric epithelium, down-regulated in gastric carcinoma, and shows high evolutionary conservation. Oien KA, et al. J Pathol, 2004 Jul. PMID 15221938
  2. A novel mitogenic protein that is highly expressed in cells of the gastric antrum mucosa. Martin TE, et al. Am J Physiol Gastrointest Liver Physiol, 2003 Aug. PMID 12851218
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in secretory granule ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gastrokine-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198972.1 → NP_945323.1  gastrokine-1 precursor

    See identical proteins and their annotated locations for NP_945323.1

    Status: PROVISIONAL

    Source sequence(s)
    AY456958
    UniProtKB/TrEMBL
    F7ETE6, Q6SJV7
    Related
    ENSRNOP00000012218.5, ENSRNOT00000012218.6
    Conserved Domains (1) summary
    smart01039
    Location:53 → 147
    BRICHOS; The BRICHOS domain is found in a variety of proteins implicated in dementia, respiratory distress and cancer

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    121347417..121352705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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