Ppp3r1 protein phosphatase 3, regulatory subunit B, alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ppp3r1provided by RGD
Official Full Name: protein phosphatase 3, regulatory subunit B, alphaprovided by RGD
Primary source: RGD:69230
See related: AllianceGenome:RGD:69230
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables phosphoprotein phosphatase activity. Involved in protein dephosphorylation. Predicted to be located in Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and sarcolemma. Predicted to be part of calcineurin complex. Predicted to be active in glutamatergic synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease and dilated cardiomyopathy. Orthologous to human PPP3R1 (protein phosphatase 3 regulatory subunit B, alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 361.5), Muscle (RPKM 249.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (95758333..95808015)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (91556743..91606391)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (100311224..100360879)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calcineurin Regulates Synaptic Plasticity and Nociceptive Transmission at the Spinal Cord Level.
Title: Calcineurin Regulates Synaptic Plasticity and Nociceptive Transmission at the Spinal Cord Level.
Ppp3r1 mRNA and protein are decreased in the hypercholesterolemic heart.
Title: MicroRNA interactome analysis predicts post-transcriptional regulation of ADRB2 and PPP3R1 in the hypercholesterolemic myocardium.
The study proposes that the structural basis of calcineurin activation by calmodulin is through displacement of the disordered fragment of the autoinhibitory domain which otherwise impedes active site access.
Title: Structural basis of calcineurin activation by calmodulin.
the calcineurin regulatory subunit, CANB1, and its catalytic binding partner PP2BA, were decreased in the fluid percussion model of traumatic brain injury in rats
Title: Detection of structural and metabolic changes in traumatically injured hippocampus by quantitative differential proteomics.
These findings reveal a novel function for CnB protein in cardiac stress response and suggest a possible application of CnB in coronary disease therapy.
Title: Calcineurin B subunit acts as a potential agent for preventing cardiac ischemia/reperfusion injury.
CaN content was affected by exposure to ammonia and glutamine; the serum content of the culture medium had a strong influence on the astroglial response to ammonium chloride, and glutamine exposure only reproduced some of the ammonia effects.
Title: Effect of ammonia, glutamine, and serum on calcineurin, p38MAPK-diP, GADD153/CHOP10, and CNTF in primary rat astrocyte cultures.
The enzymatic properties of CaN heterodimers comprised of the regulatory B subunit (CnB) with either the alpha or beta catalytic subunit were compared using in vitro phosphatase assays.
Title: Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S2724 (e-PCR)
- UniSTS:75166

BE113504 (e-PCR)
- UniSTS:246686

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent protein serine/threonine phosphatase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclosporin A binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatase binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Schwann cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelination in peripheral nervous system	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcineurin complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
located_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcineurin subunit B type 1

Names: protein phosphatase 2B regulatory subunit 1

NP_059005.1

EC 3.1.3.16

XP_006251579.3

EC 3.1.3.16

XP_063129082.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017309.3 → NP_059005.1 calcineurin subunit B type 1

See identical proteins and their annotated locations for NP_059005.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P63100

UniProtKB/TrEMBL

A6JPY9

Conserved Domains (1) summary

COG5126
Location:13 → 157

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

95758333..95808015

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006251517.5 → XP_006251579.3 calcineurin subunit B type 1 isoform X1

UniProtKB/Swiss-Prot

P63100

Conserved Domains (2) summary

PTZ00184
Location:64 → 200

PTZ00184; calmodulin; Provisional

cd00051
Location:137 → 203

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
XM_063273012.1 → XP_063129082.1 calcineurin subunit B type 1 isoform X2