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Steap1 STEAP family member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 297738, updated on 5-Mar-2024

Summary

Official Symbol
Steap1provided by RGD
Official Full Name
STEAP family member 1provided by RGD
Primary source
RGD:1311543
See related
Ensembl:ENSRNOG00000000017 AllianceGenome:RGD:1311543
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Steap
Summary
Predicted to be integral component of membrane. Predicted to be active in endosome and plasma membrane. Orthologous to several human genes including STEAP1 (STEAP family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 58.2), Uterus (RPKM 14.3) and 5 other tissues See more
Orthologs
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Genomic context

See Steap1 in Genome Data Viewer
Location:
4q13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (29231809..29242317)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (28276972..28287484)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (25435885..25446393)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 2, pseudogene 1 Neighboring gene high mobility group box 3 like 2 Neighboring gene uncharacterized LOC134486556 Neighboring gene STEAP2 metalloreductase Neighboring gene cilia and flagella associated protein 69

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
NOT enables cupric reductase activity ISO
Inferred from Sequence Orthology
more info
 
NOT enables ferric-chelate reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
 
enables heme binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
NOT acts_upstream_of_or_within copper ion import ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
STEAP1 protein
Names
metalloreductase STEAP1
six transmembrane epithelial antigen of the prostate 1
NP_001100099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106629.1NP_001100099.1  STEAP1 protein

    See identical proteins and their annotated locations for NP_001100099.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474013
    UniProtKB/TrEMBL
    A6K252, D3ZEK7
    Related
    ENSRNOP00000000018.4, ENSRNOT00000000018.8
    Conserved Domains (1) summary
    pfam01794
    Location:121264
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    29231809..29242317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)