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Ctnnal1 catenin alpha-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298019, updated on 6-Jun-2024

Summary

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Official Symbol
Ctnnal1provided by RGD
Official Full Name
catenin alpha-like 1provided by RGD
Primary source
RGD:1311434
See related
Ensembl:ENSRNOG00000010593 AllianceGenome:RGD:1311434
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Catnal1
Summary
Predicted to enable actin filament binding activity and cadherin binding activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within Rho protein signal transduction. Predicted to be located in cytosol. Orthologous to human CTNNAL1 (catenin alpha like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 105.0), Uterus (RPKM 100.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ctnnal1 in Genome Data Viewer
Location:
5q24
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (76309546..76375869, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (71514340..71569431, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (73561249..73621070, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene elongator acetyltransferase complex subunit 1 Neighboring gene actin binding transcription modulator Neighboring gene transmembrane protein 245 Neighboring gene microRNA 32 Neighboring gene ferric-chelate reductase 1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Association of Lbc Rho guanine nucleotide exchange factor with alpha-catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. Park B, et al. J Biol Chem, 2002 Nov 22. PMID 12270917
  2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
  
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-catulin
Names
catenin (cadherin associated protein), alpha-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106649.1 → NP_001100119.1  alpha-catulin

    See identical proteins and their annotated locations for NP_001100119.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474039
    UniProtKB/TrEMBL
    A0A8I6GEV6, A6KDR8, D4A739
    Related
    ENSRNOP00000014888.4, ENSRNOT00000014888.5
    Conserved Domains (1) summary
    pfam01044
    Location:91 → 674
    Vinculin; Vinculin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    76309546..76375869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287306.1 → XP_063143376.1  alpha-catulin isoform X1

    UniProtKB/TrEMBL
    A0A8I6GEV6

  2. XM_006238177.5 → XP_006238239.1  alpha-catulin isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y1A6, A0A8I6GEV6
    Related
    ENSRNOP00000077198.1
    Conserved Domains (1) summary
    pfam01044
    Location:51 → 634
    Vinculin; Vinculin family

  3. XM_039109442.2 → XP_038965370.1  alpha-catulin isoform X3

    Conserved Domains (1) summary
    pfam01044
    Location:4 → 498
    Vinculin; Vinculin family

  4. XM_039109443.1 → XP_038965371.1  alpha-catulin isoform X4

    Conserved Domains (1) summary
    pfam01044
    Location:54 → 411
    Vinculin; Vinculin family
Nucleotide Protein Strain
Heading Accession and Version

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