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Mtap methylthioadenosine phosphorylase [ Rattus norvegicus (Norway rat) ]

Gene ID: 298227, updated on 13-Apr-2024

Summary

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Official Symbol
Mtapprovided by RGD
Official Full Name
methylthioadenosine phosphorylaseprovided by RGD
Primary source
RGD:1310114
See related
Ensembl:ENSRNOG00000006615 AllianceGenome:RGD:1310114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cc1-6
Summary
Enables S-methyl-5-thioadenosine phosphorylase activity. Involved in response to testosterone. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 82.4), Adrenal (RPKM 74.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (108990270..109036494)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (103874460..103920684)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (107711077..107777530)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350998 Neighboring gene similar to human chromosome 9 open reading frame 85 Neighboring gene ARL14 effector protein-like Neighboring gene RNA N6-adenosine-methyltransferase METTL16-like Neighboring gene GSK3B interacting protein, pseudogene 1 Neighboring gene cyclin-dependent kinase inhibitor 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Label-free LC-MS/MS shotgun proteomics to investigate the anti-inflammatory effect of rCC16. Pang M, et al. Mol Med Rep, 2016 Nov. PMID 27748820, Free PMC Article
  2. Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. Karikari CA, et al. Mol Cancer Ther, 2005 Dec. PMID 16373701
  3. Androgenic regulation of 5'-deoxy-5'-methylthioadenosine concentrations and methylthioadenosine phosphorylase activity in relation to polyamine metabolism of rat prostate. Seidenfeld J, et al. Biochem Biophys Res Commun, 1980 Aug 29. PMID 6774734
  4. The stimulatory effect of testosterone propionate and 17 beta-estradiol on 5'-methylthioadenosine phosphorylase activity in rat target tissues. Nicolette JA, et al. Biochim Biophys Acta, 1980 Jan 17. PMID 6766069
  5. Occurrence of 5'-deoxy-5'-methylthioadenosine phosphorylase in the mammalian CNS: distribution and kinetic studies on the rat brain enzyme. Abbruzzese A, et al. J Neurochem, 1983 Feb. PMID 6401802

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables S-methyl-5-thioadenosine phosphorylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-methyl-5-thioadenosine phosphorylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-methionine salvage from methylthioadenosine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in L-methionine salvage from methylthioadenosine IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within methylation ISO
Inferred from Sequence Orthology
more info
  
NOT involved_in nicotinamide riboside catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
involved_in response to testosterone IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
S-methyl-5'-thioadenosine phosphorylase
Names
5'-methylthioadenosine phosphorylase
NP_001380978.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394049.1 → NP_001380978.1  S-methyl-5'-thioadenosine phosphorylase

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2K583, A6JRF0
    Related
    ENSRNOP00000073330.1, ENSRNOT00000090739.2
    Conserved Domains (1) summary
    cd09010
    Location:12 → 255
    MTAP_SsMTAPII_like_MTIP; 5'-deoxy-5'-methylthioadenosine phosphorylases (MTAP) similar to Sulfolobus solfataricus MTAPII and Pseudomonas aeruginosa PAO1 5'-methylthioinosine phosphorylase (MTIP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    108990270..109036494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001047867.1: Suppressed sequence

    Description
    NM_001047867.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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