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Pmm1 phosphomannomutase 1 [ Mus musculus (house mouse) ]

Gene ID: 29858, updated on 23-Jun-2021

Summary

Official Symbol
Pmm1provided by MGI
Official Full Name
phosphomannomutase 1provided by MGI
Primary source
MGI:MGI:1353418
See related
Ensembl:ENSMUSG00000022474
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C77612
Expression
Ubiquitous expression in cortex adult (RPKM 55.9), frontal lobe adult (RPKM 52.6) and 27 other tissues See more
Orthologs
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Genomic context

See Pmm1 in Genome Data Viewer
Location:
15; 15 E1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (81835307..81845131, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (81951106..81960930, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (81781536..81791297, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene aconitase 2, mitochondrial Neighboring gene polymerase (RNA) III (DNA directed) polypeptide H Neighboring gene cold shock domain containing C2, RNA binding Neighboring gene cytochrome P450, family 2, subfamily d, polypeptide 67, pseudogene Neighboring gene 40S ribosomal protein S14

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphomannomutase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphomannomutase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in mannose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mannose metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
phosphomannomutase 1
Names
PMM 1
Secp53 homolog
NP_001268969.1
NP_001268970.1
NP_038900.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282040.1NP_001268969.1  phosphomannomutase 1 isoform 2

    See identical proteins and their annotated locations for NP_001268969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK166999, BI731755, CX217041
    Consensus CDS
    CCDS70650.1
    UniProtKB/TrEMBL
    Q545Q8, Q91W01
    Related
    ENSMUSP00000071405.7, ENSMUST00000071462.7
    Conserved Domains (2) summary
    TIGR01484
    Location:17178
    HAD-SF-IIB; HAD-superfamily hydrolase, subfamily IIB
    cl21460
    Location:34196
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  2. NM_001282041.1NP_001268970.1  phosphomannomutase 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the 5' coding region and initiates translation at an alternate start codon, which results in a translational frameshift, compared to variant 1. The encoded isoform (3) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK166999, BI731755, CX217041
    UniProtKB/TrEMBL
    Q545Q8
    Conserved Domains (1) summary
    cl21460
    Location:86197
    HAD_like; Haloacid Dehalogenase-like Hydrolases
  3. NM_013872.4NP_038900.1  phosphomannomutase 1 isoform 1

    See identical proteins and their annotated locations for NP_038900.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK166999, BI731755, CX217041
    Consensus CDS
    CCDS27678.1
    UniProtKB/Swiss-Prot
    O35621
    UniProtKB/TrEMBL
    Q545Q8
    Related
    ENSMUSP00000023112.6, ENSMUST00000023112.12
    Conserved Domains (1) summary
    cd02585
    Location:15253
    HAD_PMM; phosphomannomutase, similar to human PMM1 and PMM2, Saccharomyces Sec53p, and Arabidopsis thaliana PMM

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    81835307..81845131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_875301.4 RNA Sequence

    Related
    ENSMUST00000229385.2
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