Cabp1 calcium binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cabp1provided by MGI
Official Full Name: calcium binding protein 1provided by MGI
Primary source: MGI:MGI:1352750
See related: Ensembl:ENSMUSG00000029544 AllianceGenome:MGI:1352750
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: caldendrin
Summary: Predicted to enable several functions, including nuclear localization sequence binding activity; transmembrane transporter binding activity; and type 3 metabotropic glutamate receptor binding activity. Involved in modification of postsynaptic actin cytoskeleton and visual perception. Is active in glutamatergic synapse. Is expressed in adrenal gland; gonad; nervous system; stomach; and vascular system. Orthologous to human CABP1 (calcium binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 57.2), frontal lobe adult (RPKM 41.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.99 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115306750..115332440, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115168691..115194381, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice.
Title: Caldendrin Is a Repressor of PIEZO2 Channels and Touch Sensation in Mice.
Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines.
Title: Caldendrin and myosin V regulate synaptic spine apparatus localization via ER stabilization in dendritic spines.
CaBP1 and CaBP2 are required for the normal function of the peripheral auditory system.
Title: Functions of CaBP1 and CaBP2 in the peripheral auditory system.
Caldendrin gene knockout results in higher synaptic actin turnover in dendritic spines.
Title: Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines.
that CaBP1 is required for cellular mechanisms underlying optimal encoding of hippocampal-dependent spatial and fear-related memories.
Title: Ca(2+)-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity.
Results show that CaBP1/caldendrin and CaBP2 are not required for normal gross retinal and synapse morphology but are necessary for the proper transmission of light responses through the retina; CaBP1/caldendrin and CaBP2 likely act by modulating presynaptic Ca(2+)-dependent signaling mechanisms.
Title: Lack of CaBP1/Caldendrin or CaBP2 Leads to Altered Ganglion Cell Responses.
Study provides the first report of the expression and localization of CaBP1 and caldendrin in the mouse brain
Title: Localization and expression of CaBP1/caldendrin in the mouse brain.
our results implicate CaBP1 rather than CaBP4 in conferring the anomalous slow inactivation of Ca(v)1.3 Ca(2+) currents required for auditory transmission
Title: Ca2+-binding proteins tune Ca2+-feedback to Cav1.3 channels in mouse auditory hair cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (3) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear localization sequence binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info
enables type 3 metabotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell communication by electrical coupling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse to nucleus signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in visual perception	IBA Inferred from Biological aspect of Ancestor more info
involved_in visual perception	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density, intracellular component	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
located_in subplasmalemmal coating	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310712.1 → NP_001297641.1 calcium-binding protein 1 isoform 1

See identical proteins and their annotated locations for NP_001297641.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI851121, KJ364651

Consensus CDS

CCDS80379.1

UniProtKB/TrEMBL

D3Z1M4

Related

ENSMUSP00000107741.2, ENSMUST00000112113.8

Conserved Domains (1) summary

PTZ00184
Location:201 → 348

PTZ00184; calmodulin; Provisional
NM_001310715.1 → NP_001297644.1 calcium-binding protein 1 isoform 3

See identical proteins and their annotated locations for NP_001297644.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC145070

Consensus CDS

CCDS80378.1

UniProtKB/Swiss-Prot

Q9JLK7

Related

ENSMUSP00000107740.2, ENSMUST00000112112.2

Conserved Domains (1) summary

PTZ00184
Location:18 → 165

PTZ00184; calmodulin; Provisional
NM_013879.2 → NP_038907.1 calcium-binding protein 1 isoform 2

See identical proteins and their annotated locations for NP_038907.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC145070

Consensus CDS

CCDS19582.1

UniProtKB/Swiss-Prot

Q9JLK6, Q9JLK7

UniProtKB/TrEMBL

Q3URT4

Related

ENSMUSP00000031519.8, ENSMUST00000031519.14

Conserved Domains (2) summary

PTZ00184
Location:78 → 225

PTZ00184; calmodulin; Provisional

cd00051
Location:163 → 226

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...