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Ints11 integrator complex subunit 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298688, updated on 30-Mar-2024

Summary

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Official Symbol
Ints11provided by RGD
Official Full Name
integrator complex subunit 11provided by RGD
Primary source
RGD:1306841
See related
Ensembl:ENSRNOG00000019712 AllianceGenome:RGD:1306841
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
int11; Cpsf3l
Summary
Predicted to enable endoribonuclease activity. Predicted to be involved in snRNA processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of integrator complex. Predicted to be active in nucleus. Orthologous to human INTS11 (integrator complex subunit 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 119.4), Lung (RPKM 114.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171761370..171779883)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166479134..166497956)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173318435..173336930)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste 1 receptor member 3 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene pseudouridine synthase like 1 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel epithelial 1 delta subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
  2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
  3. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC124975

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in snRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in snRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of integrator complex IEA
Inferred from Electronic Annotation
more info
  
part_of integrator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
integrator complex subunit 11
Names
CPSF3-like protein
cleavage and polyadenylation specific factor 3-like
cleavage and polyadenylation-specific factor 3-like protein
NP_001029064.2
XP_006239611.1
XP_006239612.1
XP_006239613.1
XP_006239614.1
XP_006239615.1
XP_017448807.1
XP_063143576.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033892.2 → NP_001029064.2  integrator complex subunit 11

    See identical proteins and their annotated locations for NP_001029064.2

    Status: VALIDATED

    Source sequence(s)
    BC105303, JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I6B2F1, A0A8L2UK86, A6IUT8
    Related
    ENSRNOP00000026725.5, ENSRNOT00000026725.5
    Conserved Domains (5) summary
    smart01027
    Location:246 → 364
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:5 → 445
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:377 → 417
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cd16291
    Location:7 → 205
    INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
    cl02570
    Location:409 → 481
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    171761370..171779883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006239549.5 → XP_006239611.1  integrator complex subunit 11 isoform X1

    UniProtKB/TrEMBL
    A0A8I6B2F1
    Conserved Domains (4) summary
    smart01027
    Location:246 → 364
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:5 → 445
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:377 → 417
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cd16291
    Location:7 → 205
    INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

  2. XM_006239550.5 → XP_006239612.1  integrator complex subunit 11 isoform X2

    UniProtKB/TrEMBL
    A0A8I6B2F1
    Conserved Domains (4) summary
    smart01027
    Location:246 → 364
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:5 → 445
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:377 → 417
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cd16291
    Location:7 → 205
    INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

  3. XM_006239551.4 → XP_006239613.1  integrator complex subunit 11 isoform X3

    UniProtKB/TrEMBL
    A0A8I6B2F1
    Conserved Domains (5) summary
    smart01027
    Location:246 → 364
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:5 → 445
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:377 → 417
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cd16291
    Location:7 → 205
    INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
    cl02570
    Location:409 → 481
    RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

  4. XM_006239553.5 → XP_006239615.1  integrator complex subunit 11 isoform X5

    UniProtKB/TrEMBL
    A0A8I6A6F2
    Conserved Domains (4) summary
    smart01027
    Location:198 → 316
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:5 → 397
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:329 → 369
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cl23716
    Location:7 → 157
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  5. XM_006239552.4 → XP_006239614.1  integrator complex subunit 11 isoform X4

    UniProtKB/TrEMBL
    A0A8I6B2F1
    Conserved Domains (4) summary
    smart01027
    Location:216 → 334
    Beta-Casp; Beta-Casp domain
    COG1236
    Location:1 → 415
    YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
    pfam07521
    Location:347 → 387
    RMMBL; RNA-metabolizing metallo-beta-lactamase
    cd16291
    Location:1 → 175
    INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

  6. XM_063287506.1 → XP_063143576.1  integrator complex subunit 11 isoform X6

  7. XM_017593318.3 → XP_017448807.1  integrator complex subunit 11 isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3MHC2.1 GenPept UniProtKB/Swiss-Prot:Q3MHC2

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