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Memo1 mediator of cell motility 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 298787, updated on 5-Mar-2024

Summary

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Official Symbol
Memo1provided by RGD
Official Full Name
mediator of cell motility 1provided by RGD
Primary source
RGD:1309929
See related
Ensembl:ENSRNOG00000006340 AllianceGenome:RGD:1309929
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309929
Summary
Predicted to be involved in regulation of microtubule-based process. Orthologous to human MEMO1 (mediator of cell motility 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 347.4), Spleen (RPKM 330.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (26895497..26986248)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (21144525..21234363)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (22362483..22409583)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L18A, pseudogene 5 Neighboring gene uncharacterized LOC120103480 Neighboring gene dpy-30 histone methyltransferase complex regulatory subunit Neighboring gene small nuclear ribonucleoprotein Sm D2-like Neighboring gene high mobility group box 2, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ErbB2 receptor controls microtubule capture by recruiting ACF7 to the plasma membrane of migrating cells. Zaoui K, et al. Proc Natl Acad Sci U S A, 2010 Oct 26. PMID 20937854, Free PMC Article
  2. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. Hu YH, et al. BMC Genomics, 2006 Jun 16. PMID 16780588, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC116222

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in regulation of microtubule-based process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of microtubule-based process ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
protein MEMO1
Names
mediator of ErbB2-driven cell motility 1
memo-1
protein memo

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029917.1 → NP_001025088.1  protein MEMO1

    See identical proteins and their annotated locations for NP_001025088.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098061
    UniProtKB/Swiss-Prot
    Q4QQR9
    UniProtKB/TrEMBL
    F1LNE5
    Related
    ENSRNOP00000008687.4, ENSRNOT00000008687.6
    Conserved Domains (1) summary
    cd07361
    Location:9 → 294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    26895497..26986248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261616.1 → XP_063117686.1  protein MEMO1 isoform X3

  2. XM_063261615.1 → XP_063117685.1  protein MEMO1 isoform X2

  3. XM_063261614.1 → XP_063117684.1  protein MEMO1 isoform X1

  4. XM_039111900.1 → XP_038967828.1  protein MEMO1 isoform X4

    UniProtKB/Swiss-Prot
    Q4QQR9
    UniProtKB/TrEMBL
    F1LNE5
    Conserved Domains (1) summary
    cd07361
    Location:9 → 294
    MEMO_like; Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility

  5. XM_039111903.2 → XP_038967831.1  protein MEMO1 isoform X5

    Conserved Domains (1) summary
    cl00599
    Location:114 → 198
    Extradiol_Dioxygenase_3B_like; Subunit B of Class III Extradiol ring-cleavage dioxygenases

RNA

  1. XR_010052056.1 RNA Sequence

  2. XR_010052055.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QQR9.1 GenPept UniProtKB/Swiss-Prot:Q4QQR9

Gene LinkOut

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