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Slc38a6 solute carrier family 38, member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 299139, updated on 2-May-2024

Summary

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Official Symbol
Slc38a6provided by RGD
Official Full Name
solute carrier family 38, member 6provided by RGD
Primary source
RGD:1310330
See related
Ensembl:ENSRNOG00000022622 AllianceGenome:RGD:1310330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Snat6
Summary
Predicted to enable L-glutamine transmembrane transporter activity. Predicted to be involved in amino acid transmembrane transport and glutamine transport. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human SLC38A6 (solute carrier family 38 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 35.0), Spleen (RPKM 34.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc38a6 in Genome Data Viewer
Location:
6q24
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (97723526..97814394)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (91987652..92076416)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (96171756..96241512)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene MNAT1 component of CDK activating kinase Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Rab geranylgeranyltransferase subunit beta, pseudogene 1 Neighboring gene tRNA methyltransferase 5 Neighboring gene ribosomal protein L26, pseudogene 13 Neighboring gene ribosomal protein L26, pseudogene 4 Neighboring gene uncharacterized LOC120103552 Neighboring gene uncharacterized LOC102550345

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Histological analysis of SLC38A6 (SNAT6) expression in mouse brain shows selective expression in excitatory neurons with high expression in the synapses. Bagchi S, et al. PLoS One, 2014. PMID 24752331, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables L-glutamate transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-glutamate transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables L-glutamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-glutamine transmembrane transporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables active monoatomic ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables neutral L-amino acid transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables secondary active transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in inorganic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neutral amino acid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 38 member 6
Names
N-system amino acid transporter 1
NAT-1
Na(+)-coupled neutral amino acid transporter 6
Na+-dependent neutral amino acid transporter
amino acid transporter SLC38A6
probable sodium-coupled neutral amino acid transporter 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013099.1 → NP_001013117.1  solute carrier family 38 member 6

    See identical proteins and their annotated locations for NP_001013117.1

    Status: PROVISIONAL

    Source sequence(s)
    AY266018
    UniProtKB/Swiss-Prot
    Q6WWW3
    UniProtKB/TrEMBL
    A6HC57, F1LRY2
    Related
    ENSRNOP00000035818.3, ENSRNOT00000029328.4
    Conserved Domains (2) summary
    COG0814
    Location:45 → 447
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:45 → 452
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    97723526..97814394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112001.2 → XP_038967929.1  solute carrier family 38 member 6 isoform X1

    UniProtKB/TrEMBL
    A6HC57, F1LRY2
    Conserved Domains (1) summary
    cl00456
    Location:45 → 430
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  2. XM_063261713.1 → XP_063117783.1  solute carrier family 38 member 6 isoform X4

  3. XM_063261716.1 → XP_063117786.1  solute carrier family 38 member 6 isoform X7

  4. XM_063261715.1 → XP_063117785.1  solute carrier family 38 member 6 isoform X6

  5. XM_039112006.2 → XP_038967934.1  solute carrier family 38 member 6 isoform X9

    Conserved Domains (1) summary
    cl00456
    Location:45 → 150
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  6. XM_006240209.3 → XP_006240271.1  solute carrier family 38 member 6 isoform X2

    See identical proteins and their annotated locations for XP_006240271.1

    UniProtKB/TrEMBL
    A6HC57, F1LRY2
    Conserved Domains (2) summary
    COG0814
    Location:2 → 392
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:2 → 397
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  7. XM_006240210.4 → XP_006240272.1  solute carrier family 38 member 6 isoform X2

    See identical proteins and their annotated locations for XP_006240272.1

    UniProtKB/TrEMBL
    A6HC57, F1LRY2
    Conserved Domains (2) summary
    COG0814
    Location:2 → 392
    SdaC; Amino acid permease [Amino acid transport and metabolism]
    cl00456
    Location:2 → 397
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

  8. XM_063261712.1 → XP_063117782.1  solute carrier family 38 member 6 isoform X3

  9. XM_063261714.1 → XP_063117784.1  solute carrier family 38 member 6 isoform X5

  10. XM_039112004.2 → XP_038967932.1  solute carrier family 38 member 6 isoform X8

    Conserved Domains (1) summary
    cl00456
    Location:45 → 245
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RNA

  1. XR_005505476.2 RNA Sequence

  2. XR_005505475.2 RNA Sequence

  3. XR_010052064.1 RNA Sequence

  4. XR_010052065.1 RNA Sequence

  5. XR_010052067.1 RNA Sequence

  6. XR_005505480.2 RNA Sequence

  7. XR_010052066.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6WWW3.1 GenPept UniProtKB/Swiss-Prot:Q6WWW3

Gene LinkOut

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