Abca7 ATP binding cassette subfamily A member 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abca7provided by RGD
Official Full Name: ATP binding cassette subfamily A member 7provided by RGD
Primary source: RGD:1303134
See related: Ensembl:ENSRNOG00000012939 AllianceGenome:RGD:1303134
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity; apolipoprotein A-I receptor activity; and floppase activity. Predicted to be involved in several processes, including lipid transport; positive regulation of transport; and regulation of MAPK cascade. Located in plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 9. Orthologous to human ABCA7 (ATP binding cassette subfamily A member 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 76.2), Spleen (RPKM 42.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 49

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (10342092..10362094, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9691452..9711466, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (12742433..12762423, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rat ABCA7 is preferentially expressed in platelets and that its apparent molecular mass is 250kDa
Title: Cloning of rat ABCA7 and its preferential expression in platelets.
Data show that rat ABCA7 is preferentially expressed in platelets and that its apparent molecular mass is 250kDa.
Title: Cloning of rat ABCA7 and its preferential expression in platelets.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139906 (e-PCR)
- UniSTS:221990

BF390650 (e-PCR)
- UniSTS:249514

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables apolipoprotein A-I receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables apolipoprotein A-I receptor activity	IEA Inferred from Electronic Annotation more info
enables apolipoprotein A-I receptor activity	ISO Inferred from Sequence Orthology more info
enables apolipoprotein A-I receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine floppase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine floppase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine floppase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine floppase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine floppase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylserine floppase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta clearance by cellular catabolic process	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta clearance by cellular catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in amyloid-beta formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in apolipoprotein A-I-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apolipoprotein A-I-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apolipoprotein A-I-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in high-density lipoprotein particle assembly	IEA Inferred from Electronic Annotation more info
involved_in high-density lipoprotein particle assembly	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of PERK-mediated unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid precursor protein biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of amyloid-beta formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phospholipid efflux	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid efflux	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in phospholipid efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid translocation	IEA Inferred from Electronic Annotation more info
involved_in phospholipid translocation	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane raft organization	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane raft organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid-beta clearance	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cholesterol efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of engulfment of apoptotic cell	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of engulfment of apoptotic cell	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phospholipid efflux	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phospholipid efflux	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to cell surface	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to cell surface	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of amyloid precursor protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid precursor protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in visual learning	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in glial cell projection	ISO Inferred from Sequence Orthology more info
located_in glial cell projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in phagocytic cup	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP-binding cassette sub-family A member 7

Names: ATP-binding cassette, sub-family A (ABC1), member 7; ATP-binding cassette, sub-family A, member 7; ATP-binding cassette, subfamily A (ABC1), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207598.2 → NP_997481.2 ATP-binding cassette sub-family A member 7

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

F1LR67

Related

ENSRNOP00000063805.2, ENSRNOT00000064886.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

10342092..10362094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240874.5 → XP_006240936.1 ATP-binding cassette sub-family A member 7 isoform X1

See identical proteins and their annotated locations for XP_006240936.1

UniProtKB/Swiss-Prot

Q7TNJ2

UniProtKB/TrEMBL

F1LR67

Conserved Domains (3) summary

TIGR01257
Location:1 → 2127

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:1818 → 2038

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

cl21474
Location:557 → 742

ABC2_membrane; ABC-2 type transporter
XM_039078645.2 → XP_038934573.1 ATP-binding cassette sub-family A member 7 isoform X2

UniProtKB/Swiss-Prot

Q7TNJ2

Conserved Domains (1) summary

TIGR01257
Location:1 → 2053

rim_protein; retinal-specific rim ABC transporter
XM_017594715.3 → XP_017450204.1 ATP-binding cassette sub-family A member 7 isoform X3

UniProtKB/Swiss-Prot

Q7TNJ2

UniProtKB/TrEMBL

A0A8I6A4A6

Related

ENSRNOP00000085552.1

Conserved Domains (3) summary

TIGR01257
Location:1 → 2040

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:1731 → 1951

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

cl21474
Location:557 → 742

ABC2_membrane; ABC-2 type transporter
XM_006240871.5 → XP_006240933.1 ATP-binding cassette sub-family A member 7 isoform X1

See identical proteins and their annotated locations for XP_006240933.1

UniProtKB/Swiss-Prot

Q7TNJ2

UniProtKB/TrEMBL

F1LR67

Conserved Domains (3) summary

TIGR01257
Location:1 → 2127

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:1818 → 2038

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

cl21474
Location:557 → 742

ABC2_membrane; ABC-2 type transporter
XM_006240872.5 → XP_006240934.1 ATP-binding cassette sub-family A member 7 isoform X1

See identical proteins and their annotated locations for XP_006240934.1

UniProtKB/Swiss-Prot

Q7TNJ2

UniProtKB/TrEMBL

F1LR67

Conserved Domains (3) summary

TIGR01257
Location:1 → 2127

rim_protein; retinal-specific rim ABC transporter

cd03263
Location:1818 → 2038

ABC_subfamily_A; ATP-binding cassette domain of the lipid transporters, subfamily A

cl21474
Location:557 → 742

ABC2_membrane; ABC-2 type transporter
XM_063263170.1 → XP_063119240.1 ATP-binding cassette sub-family A member 7 isoform X4
XM_039078646.2 → XP_038934574.1 ATP-binding cassette sub-family A member 7 isoform X5

UniProtKB/Swiss-Prot

Q7TNJ2

Conserved Domains (1) summary

TIGR01257
Location:1 → 1846

rim_protein; retinal-specific rim ABC transporter