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Vezt vezatin, adherens junctions transmembrane protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 299738, updated on 5-Mar-2024

Summary

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Official Symbol
Veztprovided by RGD
Official Full Name
vezatin, adherens junctions transmembrane proteinprovided by RGD
Primary source
RGD:1359117
See related
Ensembl:ENSRNOG00000006514 AllianceGenome:RGD:1359117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable myosin binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within chordate embryonic development. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of stereocilia ankle link complex. Predicted to be active in plasma membrane. Orthologous to human VEZT (vezatin, adherens junctions transmembrane protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 146.9), Brain (RPKM 124.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q13
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (30399208..30484429, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (28512214..28597429, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (34888487..34951712, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2 Neighboring gene ubiquitin specific peptidase 44 Neighboring gene methionyl aminopeptidase 2 Neighboring gene uncharacterized LOC120093556 Neighboring gene microRNA 331 Neighboring gene FYVE, RhoGEF and PH domain containing 6 Neighboring gene nuclear receptor subfamily 2, group C, member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex. Küssel-Andermann P, et al. EMBO J, 2000 Nov 15. PMID 11080149, Free PMC Article
  2. Vezatin, a protein associated to adherens junctions, is required for mouse blastocyst morphogenesis. Hyenne V, et al. Dev Biol, 2005 Nov 1. PMID 16199027
  3. Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning. Michalski N, et al. J Neurosci, 2007 Jun 13. PMID 17567809, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC94969

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables myosin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within chordate embryonic development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of stereocilia ankle link complex ISO
Inferred from Sequence Orthology
more info
  
part_of stereocilia ankle link complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in stereocilium membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
vezatin
Names
transmembrane protein vezatin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006984.1 → NP_001006985.1  vezatin

    See identical proteins and their annotated locations for NP_001006985.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083840
    UniProtKB/Swiss-Prot
    Q5XI52
    UniProtKB/TrEMBL
    A6IFZ9, A6IG00
    Conserved Domains (1) summary
    pfam12632
    Location:150 → 442
    Vezatin; Mysoin-binding motif of peroxisomes

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    30399208..30484429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078694.2 → XP_038934622.1  vezatin isoform X1

    UniProtKB/TrEMBL
    A6IG00
    Conserved Domains (1) summary
    pfam12632
    Location:150 → 438
    Vezatin; Mysoin-binding motif of peroxisomes

  2. XM_017594734.3 → XP_017450223.1  vezatin isoform X5

    UniProtKB/TrEMBL
    A0A8L2QL87, A6IFZ8
    Related
    ENSRNOP00000038458.5

  3. XM_039078696.2 → XP_038934624.1  vezatin isoform X3

    UniProtKB/TrEMBL
    A6IFZ8
    Conserved Domains (1) summary
    pfam12632
    Location:150 → 442
    Vezatin; Mysoin-binding motif of peroxisomes

  4. XM_063263203.1 → XP_063119273.1  vezatin isoform X6

  5. XM_039078697.2 → XP_038934625.1  vezatin isoform X4

    UniProtKB/TrEMBL
    A6IG01
    Conserved Domains (1) summary
    pfam12632
    Location:42 → 278
    Vezatin; Mysoin-binding motif of peroxisomes

  6. XM_063263202.1 → XP_063119272.1  vezatin isoform X2

RNA

  1. XR_005486572.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI52.1 GenPept UniProtKB/Swiss-Prot:Q5XI52

Gene LinkOut

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