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Kifc2 kinesin family member C2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300053, updated on 13-Apr-2024

Summary

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Official Symbol
Kifc2provided by RGD
Official Full Name
kinesin family member C2provided by RGD
Primary source
RGD:735021
See related
Ensembl:ENSRNOG00000060123 AllianceGenome:RGD:735021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement and mitotic spindle assembly. Predicted to be part of kinesin complex. Predicted to be active in microtubule cytoskeleton and nucleus. Orthologous to human KIFC2 (kinesin family member C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 314.8), Kidney (RPKM 98.7) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q34
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110261257..110269007)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108380634..108388364)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117722732..117730702)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Tmem276-zftraf1 readthrough Neighboring gene zinc finger TRAF type containing 1 Neighboring gene Transmembrane protein 276 Neighboring gene forkhead box H1 Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene glutamic--pyruvic transaminase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of KIFC2, a neuronal kinesin superfamily member in mouse. Hanlon DW, et al. Neuron, 1997 Mar. PMID 9115737
  2. Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver. Nath S, et al. Mol Biol Cell, 2007 May. PMID 17360972, Free PMC Article
  3. Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. Bhatnagar S, et al. J Biol Chem, 2014 Sep 5. PMID 25002582, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
NOT located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIFC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198752.3 → NP_942047.2  kinesin-like protein KIFC2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    Q712J1
    Related
    ENSRNOP00000074479.3, ENSRNOT00000085152.3
    Conserved Domains (2) summary
    smart00129
    Location:408 → 737
    KISc; Kinesin motor, catalytic domain. ATPase
    cd01366
    Location:406 → 733
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    110261257..110269007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078824.2 → XP_038934752.1  kinesin-like protein KIFC2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K857, A6HSC1
    Conserved Domains (1) summary
    cd01366
    Location:321 → 648
    KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

  2. XM_063263314.1 → XP_063119384.1  kinesin-like protein KIFC2 isoform X4

  3. XM_063263313.1 → XP_063119383.1  kinesin-like protein KIFC2 isoform X2

  4. XM_039078825.2 → XP_038934753.1  kinesin-like protein KIFC2 isoform X3

    Conserved Domains (1) summary
    cl22853
    Location:406 → 578
    Motor_domain; Myosin and Kinesin motor domain

  5. XM_039078826.2 → XP_038934754.1  kinesin-like protein KIFC2 isoform X5

    Conserved Domains (1) summary
    cl22853
    Location:406 → 461
    Motor_domain; Myosin and Kinesin motor domain

  6. XM_039078828.2 → XP_038934756.1  kinesin-like protein KIFC2 isoform X6

    Conserved Domains (1) summary
    cl22853
    Location:406 → 461
    Motor_domain; Myosin and Kinesin motor domain

  7. XM_039078827.2 → XP_038934755.1  kinesin-like protein KIFC2 isoform X6

    Conserved Domains (1) summary
    cl22853
    Location:406 → 461
    Motor_domain; Myosin and Kinesin motor domain
Nucleotide Protein Strain
Heading Accession and Version

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