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Gga1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300066, updated on 6-Jun-2024

Summary

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Official Symbol
Gga1provided by RGD
Official Full Name
golgi associated, gamma adaptin ear containing, ARF binding protein 1provided by RGD
Primary source
RGD:1307770
See related
Ensembl:ENSRNOG00000008897 AllianceGenome:RGD:1307770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable small GTPase binding activity. Predicted to be involved in several processes, including protein localization to cell periphery; protein localization to cell surface; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within positive regulation of protein catabolic process and toxin transport. Predicted to be located in Golgi apparatus; early endosome; and nucleoplasm. Predicted to be part of protein-containing complex. Orthologous to human GGA1 (golgi associated, gamma adaptin ear containing, ARF binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 73.6), Kidney (RPKM 50.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gga1 in Genome Data Viewer
Location:
7q34
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112316530..112332249)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110436071..110451790)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120102596..120119738)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene CDC42 effector protein 1 Neighboring gene galectin 2 Neighboring gene uncharacterized LOC134479608 Neighboring gene uncharacterized LOC120093687 Neighboring gene SH3-domain binding protein 1 Neighboring gene uncharacterized LOC134479755 Neighboring gene pyridoxal phosphatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of coat proteins changes during postnatal development in selected areas of the rat brain. Borgonovo J, et al. Int J Dev Neurosci, 2012 Jun. PMID 22306374
  2. GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Wahle T, et al. Mol Cell Neurosci, 2005 Jul. PMID 15886016
  3. Crystal structure of the human GGA1 GAT domain. Zhu G, et al. Biochemistry, 2003 Jun 3. PMID 12767220
  4. Structure of the GAT domain of human GGA1: a syntaxin amino-terminal domain fold in an endosomal trafficking adaptor. Suer S, et al. Proc Natl Acad Sci U S A, 2003 Apr 15. PMID 12668765, Free PMC Article
  5. Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport. Shiba T, et al. Nat Struct Biol, 2003 May. PMID 12679809

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC109601

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi to plasma membrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Golgi to plasma membrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to ciliary membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in retrograde transport, endosome to Golgi ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor-binding protein GGA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011994.2 → NP_001011994.1  ADP-ribosylation factor-binding protein GGA1 isoform 2

    See identical proteins and their annotated locations for NP_001011994.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6GEK9, Q5FVF3
    Related
    ENSRNOP00000086095.1, ENSRNOT00000113842.1
    Conserved Domains (4) summary
    smart00809
    Location:440 → 554
    Alpha_adaptinC2; Adaptin C-terminal domain
    cd14239
    Location:137 → 225
    GAT_GGA1_GGA2; GAT domain found in ADP-ribosylation factor (Arf)-binding proteins GGA1 and GGA2
    cl00753
    Location:107 → 161
    DUF327; Protein of unknown function (DUF327)
    cl02544
    Location:1 → 74
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

  2. NM_001399734.1 → NP_001386663.1  ADP-ribosylation factor-binding protein GGA1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6GLY6, F7FHC7
    Related
    ENSRNOP00000096170.1, ENSRNOT00000098550.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    112316530..112332249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263316.1 → XP_063119386.1  ADP-ribosylation factor-binding protein GGA1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GEK9, Q5FVF3
Nucleotide Protein Strain
Heading Accession and Version

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