Polr3h RNA polymerase III subunit H [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Polr3hprovided by RGD
Official Full Name: RNA polymerase III subunit Hprovided by RGD
Primary source: RGD:1305889
See related: Ensembl:ENSRNOG00000004471 AllianceGenome:RGD:1305889
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Predicted to be involved in transcription initiation from RNA polymerase III promoter. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of RNA polymerase III complex. Orthologous to human POLR3H (RNA polymerase III subunit H). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 222.9), Spleen (RPKM 196.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (115309571..115319881, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (113429434..113439743, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (123146248..123156558, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

RH130219 (e-PCR)
- UniSTS:213506

RH139732 (e-PCR)
- UniSTS:221816

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed 5'-3' RNA polymerase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in nucleobase-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in transcription initiation at RNA polymerase III promoter	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III subunit RPC8

Names: polymerase (RNA) III (DNA directed) polypeptide H; polymerase (RNA) III subunit H

NP_001120767.1

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127295.2 → NP_001120767.1 DNA-directed RNA polymerase III subunit RPC8

See identical proteins and their annotated locations for NP_001120767.1

Status: PROVISIONAL

Source sequence(s)

BC167088

UniProtKB/TrEMBL

A0A8I6AAU2, B2RZB0, F7FCX9

Related

ENSRNOP00000089935.1, ENSRNOT00000098323.1

Conserved Domains (2) summary

cd04330
Location:2 → 81

RNAP_III_Rpc25_N; Rpc25, N-terminal ribonucleoprotein (RNP) domain. Rpc25 is a subunit of eukaryotic RNA polymerase (RNAP) III and is homologous to Rpa43 of eukaryotic RNAP I, Rpb7 of eukaryotic RNAP II, and RpoE of archaeal RNAP. Rpc25 has two domains, an N-terminal RNP ...

pfam08292
Location:83 → 201

RNA_pol_Rbc25; RNA polymerase III subunit Rpc25