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Timm9 translocase of inner mitochondrial membrane 9 [ Mus musculus (house mouse) ]

Gene ID: 30056, updated on 5-Mar-2024

Summary

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Official Symbol
Timm9provided by MGI
Official Full Name
translocase of inner mitochondrial membrane 9provided by MGI
Primary source
MGI:MGI:1353436
See related
Ensembl:ENSMUSG00000021079 AllianceGenome:MGI:1353436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tim10a; Timm10; 2810011L15Rik
Summary
Predicted to enable chaperone binding activity; membrane insertase activity; and protein homodimerization activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Part of mitochondrial intermembrane space protein transporter complex. Is expressed in genitourinary system; orbito-sphenoid; otic capsule; and telencephalon ventricular layer. Orthologous to human TIMM9 (translocase of inner mitochondrial membrane 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 12.2), frontal lobe adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 C2; 12 29.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (71169946..71183476, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (71123172..71136708, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110056K07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72116322-72116431 Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:72116588-72116697 Neighboring gene STARR-seq mESC enhancer starr_32414 Neighboring gene AT-rich interaction domain 4A Neighboring gene STARR-positive B cell enhancer ABC_E7145 Neighboring gene STARR-seq mESC enhancer starr_32415 Neighboring gene RIKEN cDNA 2700049A03 gene Neighboring gene translocase of outer mitochondrial membrane 20-like Neighboring gene predicted gene, 32906 Neighboring gene STARR-positive B cell enhancer ABC_E918 Neighboring gene STARR-positive B cell enhancer ABC_E10758 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene 7959

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. Jin H, et al. Genomics, 1999 Nov 1. PMID 10552927
  2. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. Mühlenbein N, et al. J Biol Chem, 2004 Apr 2. PMID 14726512
  3. The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. Bauer MF, et al. FEBS Lett, 1999 Dec 24. PMID 10611480
  4. Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment. Georgas K, et al. Dev Biol, 2009 Aug 15. PMID 19501082
  5. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-folding chaperone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein insertion into mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein insertion into mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of TIM22 mitochondrial import inner membrane insertion complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial intermembrane space protein transporter complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mitochondrial intermembrane space protein transporter complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit Tim9
Names
translocase of inner mitochondrial membrane 10 homolog
translocase of inner mitochondrial membrane 9 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024853.1 → NP_001020024.1  mitochondrial import inner membrane translocase subunit Tim9

    See identical proteins and their annotated locations for NP_001020024.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC159620, AI848414, DV652207
    Consensus CDS
    CCDS25962.1
    UniProtKB/Swiss-Prot
    Q9WV98
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  2. NM_001024854.1 → NP_001020025.1  mitochondrial import inner membrane translocase subunit Tim9

    See identical proteins and their annotated locations for NP_001020025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC159620, AI848414, AK018764
    Consensus CDS
    CCDS25962.1
    UniProtKB/Swiss-Prot
    Q9WV98
    Related
    ENSMUSP00000021486.9, ENSMUST00000021486.10
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  3. NM_001286203.2 → NP_001273132.1  mitochondrial import inner membrane translocase subunit Tim9

    See identical proteins and their annotated locations for NP_001273132.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an internal exon in the 5' UTR, compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AC159620, AF150101, AI848414
    Consensus CDS
    CCDS25962.1
    UniProtKB/Swiss-Prot
    Q9WV98
    Related
    ENSMUSP00000152455.2, ENSMUST00000221559.2
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  4. NM_013896.3 → NP_038924.1  mitochondrial import inner membrane translocase subunit Tim9

    See identical proteins and their annotated locations for NP_038924.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AC159620, AI119857, AI848414, CK626183
    Consensus CDS
    CCDS25962.1
    UniProtKB/Swiss-Prot
    Q9WV98
    Related
    ENSMUSP00000126298.2, ENSMUST00000166120.9
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    71169946..71183476 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157467.1 → XP_036013360.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

    UniProtKB/Swiss-Prot
    Q9WV98
    Related
    ENSMUSP00000152114.2, ENSMUST00000220482.2
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  2. XM_011244122.4 → XP_011242424.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

    See identical proteins and their annotated locations for XP_011242424.1

    UniProtKB/Swiss-Prot
    Q9WV98
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  3. XM_036157466.1 → XP_036013359.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

    UniProtKB/Swiss-Prot
    Q9WV98
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger

  4. XM_017315088.3 → XP_017170577.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

    UniProtKB/Swiss-Prot
    Q9WV98
    Conserved Domains (1) summary
    pfam02953
    Location:10 → 67
    zf-Tim10_DDP; Tim10/DDP family zinc finger
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV98.1 GenPept UniProtKB/Swiss-Prot:Q9WV98

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