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Mto1 mitochondrial tRNA translation optimization 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300852, updated on 5-Mar-2024

Summary

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Official Symbol
Mto1provided by RGD
Official Full Name
mitochondrial tRNA translation optimization 1provided by RGD
Primary source
RGD:1308830
See related
Ensembl:ENSRNOG00000037659 AllianceGenome:RGD:1308830
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable flavin adenine dinucleotide binding activity. Predicted to be involved in mitochondrial tRNA wobble uridine modification and tRNA methylation. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 83.6), Kidney (RPKM 83.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mto1 in Genome Data Viewer
Location:
8q31
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (88188918..88215516)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (79309681..79335231)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85807703..85832263)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene oocyte expressed protein Neighboring gene DEAD-box helicase 43 Neighboring gene trafficking protein particle complex subunit 14 like 1 Neighboring gene cyclic GMP-AMP synthase Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene uncharacterized LOC134480209

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CircMTO1 Attenuated Acute Kidney Injury Through Regulating miR-337. Shi CC, et al. Inflammation, 2020 Aug. PMID 32157506, Free PMC Article
  2. Identification and characterization of mouse MTO1 gene related to mitochondrial tRNA modification. Li R, et al. Biochim Biophys Acta, 2003 Oct 1. PMID 14522080
  3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CircMTO1 Attenuated Acute Kidney Injury Through Regulating miR-337.
    Title: CircMTO1 Attenuated Acute Kidney Injury Through Regulating miR-337.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrial tRNA wobble uridine modification ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA wobble uridine modification ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein MTO1 homolog, mitochondrial
Names
mitochondrial translation optimization 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106841.1 → NP_001100311.1  protein MTO1 homolog, mitochondrial

    See identical proteins and their annotated locations for NP_001100311.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473954
    UniProtKB/TrEMBL
    A6I1J8, F1LYH3
    Related
    ENSRNOP00000053966.5, ENSRNOT00000057138.5
    Conserved Domains (3) summary
    PRK05192
    Location:56 → 669
    PRK05192; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
    pfam13932
    Location:437 → 653
    GIDA_assoc; GidA associated domain
    cl21454
    Location:357 → 455
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    88188918..88215516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081156.2 → XP_038937084.1  protein MTO1 homolog, mitochondrial isoform X1

    Conserved Domains (1) summary
    PRK05192
    Location:72 → 563
    PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG

  2. XM_039081158.2 → XP_038937086.1  protein MTO1 homolog, mitochondrial isoform X3

    Conserved Domains (1) summary
    PRK05192
    Location:56 → 419
    PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG

  3. XM_039081157.2 → XP_038937085.1  protein MTO1 homolog, mitochondrial isoform X2

    Conserved Domains (1) summary
    PRK05192
    Location:2 → 487
    PRK05192; tRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG
Nucleotide Protein Strain
Heading Accession and Version

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