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Tfdp2 transcription factor Dp-2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 300947, updated on 3-Apr-2024

Summary

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Official Symbol
Tfdp2provided by RGD
Official Full Name
transcription factor Dp-2provided by RGD
Primary source
RGD:1305814
See related
Ensembl:ENSRNOG00000011241 AllianceGenome:RGD:1305814
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tcfdp2
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and protein domain specific binding activity. Predicted to contribute to DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in heart development. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TFDP2 (transcription factor Dp-2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 168.5), Spleen (RPKM 136.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tfdp2 in Genome Data Viewer
Location:
8q31
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (105640018..105781026)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96760459..96901466)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (104040795..104181228)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094234 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene glycerol kinase 5 Neighboring gene uncharacterized LOC134480216 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene ATP synthase peripheral stalk-membrane subunit b, pseudogene 1 Neighboring gene 60S ribosomal protein L31-like Neighboring gene ATPase Na+/K+ transporting subunit beta 3 Neighboring gene ubiquitin conjugating enzyme E2 V1, pseudogene 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of E2F abrogates the development of cardiac myocyte hypertrophy. Vara D, et al. J Biol Chem, 2003 Jun 13. PMID 12682052
  2. E2F-6, a member of the E2F family that can behave as a transcriptional repressor. Trimarchi JM, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501179, Free PMC Article
  3. Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes. Zaragoza K, et al. Mol Cell Biol, 2010 May. PMID 20176812, Free PMC Article
  4. In vivo association of E2F and DP family proteins. Wu CL, et al. Mol Cell Biol, 1995 May. PMID 7739537, Free PMC Article
  5. Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release. Rubin SM, et al. Cell, 2005 Dec 16. PMID 16360038

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heart development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
transcription factor Dp-2
Names
transcription factor Dp-2 (E2F dimerization partner 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001106847.2 → NP_001100317.2  transcription factor Dp-2

    See identical proteins and their annotated locations for NP_001100317.2

    Status: PROVISIONAL

    Source sequence(s)
    BC168961
    UniProtKB/TrEMBL
    A0A8I5ZNQ2, B5DF82
    Related
    ENSRNOP00000015014.6, ENSRNOT00000015015.7
    Conserved Domains (3) summary
    cd14458
    Location:152 → 198
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68 → 147
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:154 → 293
    DP; Transcription factor DP

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    105640018..105781026
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595584.3 → XP_017451073.1  transcription factor Dp-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:213 → 259
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 208
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:215 → 354
    DP; Transcription factor DP

  2. XM_017595583.3 → XP_017451072.1  transcription factor Dp-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXE8, A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:214 → 260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216 → 354
    DP; Transcription factor DP

  3. XM_006243556.5 → XP_006243618.1  transcription factor Dp-2 isoform X1

    See identical proteins and their annotated locations for XP_006243618.1

    UniProtKB/TrEMBL
    A0A0G2JXE8, A0A8I5ZNQ2
    Related
    ENSRNOP00000070243.2
    Conserved Domains (3) summary
    cd14458
    Location:214 → 260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216 → 354
    DP; Transcription factor DP

  4. XM_017595585.3 → XP_017451074.1  transcription factor Dp-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:214 → 260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216 → 355
    DP; Transcription factor DP

  5. XM_063265216.1 → XP_063121286.1  transcription factor Dp-2 isoform X5

  6. XM_063265213.1 → XP_063121283.1  transcription factor Dp-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXE8

  7. XM_017595582.3 → XP_017451071.1  transcription factor Dp-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXE8, A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:214 → 260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216 → 354
    DP; Transcription factor DP

  8. XM_039081176.2 → XP_038937104.1  transcription factor Dp-2 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZNQ2, A0A8I6A268
    Conserved Domains (3) summary
    cd14458
    Location:154 → 200
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:69 → 149
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:156 → 294
    DP; Transcription factor DP

  9. XM_039081178.2 → XP_038937106.1  transcription factor Dp-2 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZNQ2, A0A8I6A268
    Conserved Domains (3) summary
    cd14458
    Location:154 → 200
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:69 → 149
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:156 → 294
    DP; Transcription factor DP

  10. XM_039081174.2 → XP_038937102.1  transcription factor Dp-2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JXE8, A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:214 → 260
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:129 → 209
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:216 → 354
    DP; Transcription factor DP

  11. XM_063265215.1 → XP_063121285.1  transcription factor Dp-2 isoform X2

  12. XM_039081183.2 → XP_038937111.1  transcription factor Dp-2 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:117 → 163
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:32 → 112
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:119 → 257
    DP; Transcription factor DP

  13. XM_063265220.1 → XP_063121290.1  transcription factor Dp-2 isoform X9

    UniProtKB/TrEMBL
    A0A8I6A268

  14. XM_063265222.1 → XP_063121292.1  transcription factor Dp-2 isoform X11

  15. XM_039081180.1 → XP_038937108.1  transcription factor Dp-2 isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZNQ2, A0A8I6A8L4
    Related
    ENSRNOP00000089626.1, ENSRNOT00000108693.1
    Conserved Domains (3) summary
    cd14458
    Location:153 → 199
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:68 → 148
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:155 → 293
    DP; Transcription factor DP

  16. XM_063265217.1 → XP_063121287.1  transcription factor Dp-2 isoform X6

    UniProtKB/TrEMBL
    F7EWM8

  17. XM_006243561.5 → XP_006243623.1  transcription factor Dp-2 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:197 → 243
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:112 → 192
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:199 → 338
    DP; Transcription factor DP

  18. XM_063265218.1 → XP_063121288.1  transcription factor Dp-2 isoform X7

  19. XM_063265219.1 → XP_063121289.1  transcription factor Dp-2 isoform X8

  20. XM_039081186.2 → XP_038937114.1  transcription factor Dp-2 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:117 → 163
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:32 → 112
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:119 → 257
    DP; Transcription factor DP

  21. XM_039081185.2 → XP_038937113.1  transcription factor Dp-2 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:117 → 163
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:32 → 112
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:119 → 257
    DP; Transcription factor DP

  22. XM_039081187.2 → XP_038937115.1  transcription factor Dp-2 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:117 → 163
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:32 → 112
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:119 → 257
    DP; Transcription factor DP

  23. XM_063265221.1 → XP_063121291.1  transcription factor Dp-2 isoform X10

    UniProtKB/TrEMBL
    A0A8I6A8L4

  24. XM_039081184.2 → XP_038937112.1  transcription factor Dp-2 isoform X11

    UniProtKB/TrEMBL
    A0A8I5ZNQ2
    Conserved Domains (3) summary
    cd14458
    Location:117 → 163
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:32 → 112
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:119 → 257
    DP; Transcription factor DP

  25. XM_039081179.1 → XP_038937107.1  transcription factor Dp-2 isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZNQ2, A0A8I6A268
    Related
    ENSRNOP00000085683.1, ENSRNOT00000112993.1
    Conserved Domains (3) summary
    cd14458
    Location:154 → 200
    DP_DD; coiled coil [structural motif]
    pfam02319
    Location:69 → 149
    E2F_TDP; E2F/DP family winged-helix DNA-binding domain
    pfam08781
    Location:156 → 294
    DP; Transcription factor DP
Nucleotide Protein Strain
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