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Uba7 ubiquitin-like modifier activating enzyme 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301000, updated on 30-Mar-2024

Summary

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Official Symbol
Uba7provided by RGD
Official Full Name
ubiquitin-like modifier activating enzyme 7provided by RGD
Primary source
RGD:1308323
See related
Ensembl:ENSRNOG00000029195 AllianceGenome:RGD:1308323
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ube1l
Summary
Predicted to enable ISG15 activating enzyme activity and ubiquitin-protein transferase activity. Predicted to be involved in ISG15-protein conjugation and cellular response to DNA damage stimulus. Predicted to act upstream of or within modification-dependent protein catabolic process. Predicted to be active in cytoplasm and nucleus. Orthologous to human UBA7 (ubiquitin like modifier activating enzyme 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 65.3), Spleen (RPKM 55.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
8q32
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117543902..117552709)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108665289..108674097)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116754178..116766765)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene CaM kinase-like vesicle-associated Neighboring gene TRAF-interacting protein Neighboring gene inka box actin regulator 1 Neighboring gene uncharacterized LOC134480233 Neighboring gene cadherin-related family member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. ISG15 Arg151 and the ISG15-conjugating enzyme UbE1L are important for innate immune control of Sindbis virus. Giannakopoulos NV, et al. J Virol, 2009 Feb. PMID 19073728, Free PMC Article
  2. Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling. Kim KI, et al. Mol Cell Biol, 2006 Jan. PMID 16382139, Free PMC Article
  3. The basis for selective E1-E2 interactions in the ISG15 conjugation system. Durfee LA, et al. J Biol Chem, 2008 Aug 29. PMID 18583345, Free PMC Article
  4. Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme. Takeuchi T, et al. J Biochem, 2005 Dec. PMID 16428300
  5. Proteomic identification of proteins conjugated to ISG15 in mouse and human cells. Giannakopoulos NV, et al. Biochem Biophys Res Commun, 2005 Oct 21. PMID 16139798

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ISG15 activating enzyme activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ISG15 activating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin activating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ISG15-protein conjugation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ISG15-protein conjugation ISO
Inferred from Sequence Orthology
more info
  
involved_in ISG15-protein conjugation ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within modification-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin-like modifier-activating enzyme 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393920.1 → NP_001380849.1  ubiquitin-like modifier-activating enzyme 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A0G2K735
    Related
    ENSRNOP00000074046.2, ENSRNOT00000084429.2
    Conserved Domains (1) summary
    TIGR01408
    Location:1 → 988
    Ube1; ubiquitin-activating enzyme E1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    117543902..117552709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006243741.4 → XP_006243803.1  ubiquitin-like modifier-activating enzyme 7 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K735
    Conserved Domains (4) summary
    cd01491
    Location:5 → 386
    Ube1_repeat1; Ubiquitin activating enzyme (E1), repeat 1. E1, a highly conserved small protein present universally in eukaryotic cells, is part of cascade to attach ubiquitin (Ub) covalently to substrate proteins. This cascade consists of activating (E1), conjugating ...
    TIGR01408
    Location:1 → 987
    Ube1; ubiquitin-activating enzyme E1
    pfam16191
    Location:254 → 317
    E1_4HB; Ubiquitin-activating enzyme E1 four-helix bundle
    cl22428
    Location:421 → 944
    E1_enzyme_family; Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common ...

  2. XM_039081230.2 → XP_038937158.1  ubiquitin-like modifier-activating enzyme 7 isoform X2

    Conserved Domains (1) summary
    TIGR01408
    Location:1 → 952
    Ube1; ubiquitin-activating enzyme E1

  3. XM_039081231.2 → XP_038937159.1  ubiquitin-like modifier-activating enzyme 7 isoform X3

    Conserved Domains (1) summary
    TIGR01408
    Location:1 → 951
    Ube1; ubiquitin-activating enzyme E1

  4. XM_039081233.2 → XP_038937161.1  ubiquitin-like modifier-activating enzyme 7 isoform X5

    Related
    ENSRNOP00000062984.1
    Conserved Domains (1) summary
    TIGR01408
    Location:1 → 728
    Ube1; ubiquitin-activating enzyme E1

  5. XM_039081232.2 → XP_038937160.1  ubiquitin-like modifier-activating enzyme 7 isoform X4

    Conserved Domains (1) summary
    TIGR01408
    Location:5 → 863
    Ube1; ubiquitin-activating enzyme E1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001106856.1: Suppressed sequence

    Description
    NM_001106856.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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