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Mocs1 molybdenum cofactor synthesis 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301221, updated on 13-Apr-2024

Summary

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Official Symbol
Mocs1provided by RGD
Official Full Name
molybdenum cofactor synthesis 1provided by RGD
Primary source
RGD:1308471
See related
Ensembl:ENSRNOG00000011784 AllianceGenome:RGD:1308471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 4 iron, 4 sulfur cluster binding activity; GTP 3',8'-cyclase activity; and cyclic pyranopterin monophosphate synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to act upstream of or within molybdopterin cofactor biosynthetic process. Predicted to be located in cytosol. Predicted to be part of molybdopterin synthase complex. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 137.6), Kidney (RPKM 108.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (19045223..19071628, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (11547533..11573935, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (13493705..13513972, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene kinesin family member 6 Neighboring gene uncharacterized LOC134480334 Neighboring gene dishevelled associated activator of morphogenesis 2 Neighboring gene uncharacterized LOC134480336 Neighboring gene uncharacterized LOC120094630 Neighboring gene uncharacterized LOC108351887 Neighboring gene ribosomal protein L5, pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Long-term rescue of a lethal inherited disease by adeno-associated virus-mediated gene transfer in a mouse model of molybdenum-cofactor deficiency. Kügler S, et al. Am J Hum Genet, 2007 Feb. PMID 17236133, Free PMC Article
  2. The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis. Reiss J, et al. Mol Genet Metab, 2005 May. PMID 15862276
  3. Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis. Hänzelmann P, et al. J Biol Chem, 2004 Aug 13. PMID 15180982
  4. Molybdenum cofactor-deficient mice resemble the phenotype of human patients. Lee HJ, et al. Hum Mol Genet, 2002 Dec 15. PMID 12471057
  5. Genomic structure and mutational spectrum of the bicistronic MOCS1 gene defective in molybdenum cofactor deficiency type A. Reiss J, et al. Hum Genet, 1998 Dec. PMID 9921896

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP 3',8'-cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP 3',8'-cyclase activity ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables S-adenosyl-L-methionine binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclic pyranopterin monophosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclic pyranopterin monophosphate synthase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Mo-molybdopterin cofactor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within molybdopterin cofactor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in molybdopterin cofactor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of molybdopterin synthase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
molybdenum cofactor biosynthesis protein 1
NP_001400697.1
XP_008765063.1
XP_038939095.1
XP_038939096.1
XP_038939097.1
XP_038939099.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413768.1 → NP_001400697.1  molybdenum cofactor biosynthesis protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6GKB1, A6JIC9
    Related
    ENSRNOP00000092719.1, ENSRNOT00000105120.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    19045223..19071628 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083167.2 → XP_038939095.1  molybdenum cofactor biosynthesis protein 1 isoform X1

    Conserved Domains (2) summary
    PLN02951
    Location:60 → 400
    PLN02951; Molybderin biosynthesis protein CNX2
    PRK09364
    Location:495 → 652
    moaC; cyclic pyranopterin monophosphate synthase MoaC

  2. XM_039083168.2 → XP_038939096.1  molybdenum cofactor biosynthesis protein 1 isoform X2

    Conserved Domains (2) summary
    PLN02951
    Location:1 → 185
    PLN02951; Molybderin biosynthesis protein CNX2
    PRK09364
    Location:280 → 437
    moaC; cyclic pyranopterin monophosphate synthase MoaC

  3. XM_039083171.2 → XP_038939099.1  molybdenum cofactor biosynthesis protein 1 isoform X5

    Conserved Domains (2) summary
    PLN02951
    Location:1 → 124
    PLN02951; Molybderin biosynthesis protein CNX2
    PRK09364
    Location:219 → 376
    moaC; cyclic pyranopterin monophosphate synthase MoaC

  4. XM_039083169.2 → XP_038939097.1  molybdenum cofactor biosynthesis protein 1 isoform X3

    Conserved Domains (1) summary
    PLN02951
    Location:60 → 401
    PLN02951; Molybderin biosynthesis protein CNX2

  5. XM_008766841.4 → XP_008765063.1  molybdenum cofactor biosynthesis protein 1 isoform X4

    UniProtKB/TrEMBL
    A6JIC8, D3ZVG1
    Conserved Domains (3) summary
    cd01335
    Location:74 → 272
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    PLN02951
    Location:7 → 385
    PLN02951; Molybderin biosynthesis protein CNX2
    pfam06463
    Location:241 → 367
    Mob_synth_C; Molybdenum Cofactor Synthesis C
Nucleotide Protein Strain
Heading Accession and Version

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