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Arhgef4 Rho guanine nucleotide exchange factor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301334, updated on 13-Apr-2024

Summary

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Official Symbol
Arhgef4provided by RGD
Official Full Name
Rho guanine nucleotide exchange factor 4provided by RGD
Primary source
RGD:1586179
See related
Ensembl:ENSRNOG00000014035 AllianceGenome:RGD:1586179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable guanyl-nucleotide exchange factor activity and protein domain specific binding activity. Predicted to be involved in filopodium assembly and lamellipodium assembly. Orthologous to human ARHGEF4 (Rho guanine nucleotide exchange factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 152.4), Thymus (RPKM 45.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Arhgef4 in Genome Data Viewer
Location:
9q21
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (44357716..44500959)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (36861800..37005079)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (41160562..41305015)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene thymosin beta-10-like Neighboring gene ribosomal protein lateral stalk subunit P1, pseudogene 1 Neighboring gene uncharacterized LOC120094663 Neighboring gene small integral membrane protein 39 Neighboring gene family with sequence similarity 168, member B Neighboring gene uncharacterized LOC120094662 Neighboring gene pleckstrin homology domain containing B2 Neighboring gene U1 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Adenomatous polyposis coli-stimulated GEF 1 (Asef1) is a negative regulator of excitatory synaptic function. Oh JY, et al. J Neurochem, 2018 Dec. PMID 30125942
  2. Activity of Arhgef4 is modulated through Staufen1 in neurons. Lee K, et al. Neurosci Lett, 2021 Jun 21. PMID 34022264
  3. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Kawasaki Y, et al. Oncogene, 2007 Dec 6. PMID 17599059
  4. Asef, a link between the tumor suppressor APC and G-protein signaling. Kawasaki Y, et al. Science, 2000 Aug 18. PMID 10947987
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activity of Arhgef4 is modulated through Staufen1 in neurons.
    Title: Activity of Arhgef4 is modulated through Staufen1 in neurons.
  2. our data reveal Arhgef4 functions as a negative regulator of synaptic localization of PSD-95 and synaptic transmission
    Title: Adenomatous polyposis coli-stimulated GEF 1 (Asef1) is a negative regulator of excitatory synaptic function.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 4
Names
Rho guanine nucleotide exchange factor (GEF) 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427642.1 → NP_001414571.1  rho guanine nucleotide exchange factor 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    D3ZKB4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    44357716..44500959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084525.2 → XP_038940453.1  rho guanine nucleotide exchange factor 4 isoform X2

    Conserved Domains (3) summary
    cd11973
    Location:1141 → 1213
    SH3_ASEF; Src homology 3 domain of APC-Stimulated guanine nucleotide Exchange Factor
    smart00325
    Location:1250 → 1429
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01224
    Location:1434 → 1573
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain

  2. XM_063266890.1 → XP_063122960.1  rho guanine nucleotide exchange factor 4 isoform X4

  3. XM_017596787.3 → XP_017452276.1  rho guanine nucleotide exchange factor 4 isoform X1

  4. XM_063266889.1 → XP_063122959.1  rho guanine nucleotide exchange factor 4 isoform X3

  5. XM_063266891.1 → XP_063122961.1  rho guanine nucleotide exchange factor 4 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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