U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fbxo11 F-box protein 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 301674, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Symbol
Fbxo11provided by RGD
Full Name
F-box protein 11provided by RGD
Primary source
RGD:727935
See related
Ensembl:ENSRNOG00000016396 AllianceGenome:RGD:727935
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vit1
Summary
Predicted to enable protein-arginine N-methyltransferase activity and ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination; regulation of apoptotic process; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within sensory perception of sound. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 130.9), Spleen (RPKM 100.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
6q12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (12240348..12316223)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (6486761..6562664)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (11662356..11737427, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene H2A.Z variant histone 1, pseudogene 2 Neighboring gene uncharacterized LOC120103457 Neighboring gene uncharacterized LOC120103458 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1, pseudogene 3 Neighboring gene uncharacterized LOC134479271 Neighboring gene mutS homolog 6 Neighboring gene potassium two pore domain channel subfamily K member 12 Neighboring gene uncharacterized LOC120103460

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. miR-324-5p upregulation potentiates resistance to cisplatin by targeting FBXO11 signalling in non-small cell lung cancer cells. Ba Z, et al. J Biochem, 2019 Dec 1. PMID 31778188
  2. Modulation of Ca(2+)-induced Ca(2+) release by ubiquitin protein ligase E3 component n-recognin UBR3 and 6 in cardiac myocytes. Ma XE, et al. Channels (Austin), 2020 Dec. PMID 32988261, Free PMC Article
  3. LINC01436, regulating miR-585 and FBXO11, is an oncogenic lncRNA in the progression of gastric cancer. Zhang Y, et al. Cell Biol Int, 2020 Mar. PMID 31829474
  4. F-box protein 11 promotes the growth and metastasis of gastric cancer via PI3K/AKT pathway-mediated EMT. Sun C, et al. Biomed Pharmacother, 2018 Feb. PMID 29278851
  5. A mutation in the F-box gene, Fbxo11, causes otitis media in the Jeff mouse. Hardisty-Hughes RE, et al. Hum Mol Genet, 2006 Nov 15. PMID 17035249

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sound IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
F-box only protein 11
Names
F-box only protein 11-like

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181631.2 → NP_853662.1  F-box only protein 11

    See identical proteins and their annotated locations for NP_853662.1

    Status: PROVISIONAL

    Source sequence(s)
    AY274810
    UniProtKB/Swiss-Prot
    Q7TSL3
    UniProtKB/TrEMBL
    A6H9C5
    Conserved Domains (3) summary
    pfam12937
    Location:73 → 116
    F-box-like
    pfam13229
    Location:580 → 739
    Beta_helix; Right handed beta helix region
    cl19744
    Location:766 → 807
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    12240348..12316223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112126.2 → XP_038968054.1  F-box only protein 11 isoform X1

    UniProtKB/TrEMBL
    A0A8L2QBJ7
    Related
    ENSRNOP00000021998.5
    Conserved Domains (3) summary
    pfam12937
    Location:163 → 206
    F-box-like
    pfam13229
    Location:670 → 829
    Beta_helix; Right handed beta helix region
    cl19744
    Location:856 → 897
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  2. XM_039112127.2 → XP_038968055.1  F-box only protein 11 isoform X2

    Conserved Domains (3) summary
    pfam12937
    Location:162 → 205
    F-box-like
    pfam13229
    Location:669 → 828
    Beta_helix; Right handed beta helix region
    cl19744
    Location:855 → 896
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  3. XM_017594113.3 → XP_017449602.1  F-box only protein 11 isoform X4

    UniProtKB/Swiss-Prot
    Q7TSL3
    UniProtKB/TrEMBL
    A6H9C5
    Conserved Domains (3) summary
    pfam12937
    Location:73 → 116
    F-box-like
    pfam13229
    Location:580 → 739
    Beta_helix; Right handed beta helix region
    cl19744
    Location:766 → 807
    zf-UBR; Putative zinc finger in N-recognin (UBR box)

  4. XM_063261802.1 → XP_063117872.1  F-box only protein 11 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSL3.1 GenPept UniProtKB/Swiss-Prot:Q7TSL3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous