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Tspan6 tetraspanin 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 302313, updated on 11-Apr-2024

Summary

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Official Symbol
Tspan6provided by RGD
Official Full Name
tetraspanin 6provided by RGD
Primary source
RGD:1560160
See related
Ensembl:ENSRNOG00000003786 AllianceGenome:RGD:1560160
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in negative regulation of NIK/NF-kappaB signaling; negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be integral component of plasma membrane. Orthologous to human TSPAN6 (tetraspanin 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 652.9), Lung (RPKM 120.7) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tspan6 in Genome Data Viewer
Location:
Xq32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (101385686..101395371, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (97092394..97099659, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (104719930..104729606, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene tenomodulin Neighboring gene sushi-repeat-containing protein, X-linked 2 Neighboring gene synaptotagmin-like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tetraspanin 6 (TSPAN6) negatively regulates retinoic acid-inducible gene I-like receptor-mediated immune signaling in a ubiquitination-dependent manner. Wang Y, et al. J Biol Chem, 2012 Oct 5. PMID 22908223, Free PMC Article
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. Matsuda A, et al. Oncogene, 2003 May 22. PMID 12761501
  3. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  4. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
tetraspanin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100672.1 → NP_001094142.1  tetraspanin-6

    See identical proteins and their annotated locations for NP_001094142.1

    Status: PROVISIONAL

    Source sequence(s)
    BC158651
    UniProtKB/TrEMBL
    A0A8I6A7Q5, B0BN20, F7ESS4
    Related
    ENSRNOP00000088359.1, ENSRNOT00000119163.1
    Conserved Domains (1) summary
    pfam00335
    Location:17 → 233
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    101385686..101395371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008773408.4 → XP_008771630.1  tetraspanin-6 isoform X2

    Conserved Domains (2) summary
    cd03161
    Location:24 → 121
    TM4SF2_6_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1 → 149
    Tetraspannin; Tetraspanin family

  2. XM_063279888.1 → XP_063135958.1  tetraspanin-6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7Q5, B0BN20
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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