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Haghl hydroxyacylglutathione hydrolase-like [ Rattus norvegicus (Norway rat) ]

Gene ID: 302995, updated on 9-May-2024

Summary

Official Symbol
Haghlprovided by RGD
Official Full Name
hydroxyacylglutathione hydrolase-likeprovided by RGD
Primary source
RGD:1308042
See related
Ensembl:ENSRNOG00000019612 AllianceGenome:RGD:1308042
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Orthologous to human HAGHL (hydroxyacylglutathione hydrolase like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 48.7), Thymus (RPKM 22.9) and 9 other tissues See more
Orthologs
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Genomic context

See Haghl in Genome Data Viewer
Location:
10q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (15309469..15313910, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14804957..14809495, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (15152736..15157221, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene mesothelin Neighboring gene cytosolic iron-sulfur assembly component 3 Neighboring gene coiled-coil domain containing 78 Neighboring gene adenine nucleotide translocase lysine methyltransferase Neighboring gene meteorin, glial cell differentiation regulator

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General protein information

Preferred Names
hydroxyacylglutathione hydrolase-like protein
XP_006246126.1
XP_006246127.1
XP_038943040.1
XP_063126164.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430179.1NP_001417108.1  hydroxyacylglutathione hydrolase-like protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    15309469..15313910 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246064.5XP_006246126.1  hydroxyacylglutathione hydrolase-like protein isoform X1

    See identical proteins and their annotated locations for XP_006246126.1

    Conserved Domains (1) summary
    PLN02469
    Location:1272
    PLN02469; hydroxyacylglutathione hydrolase
  2. XM_039087112.2XP_038943040.1  hydroxyacylglutathione hydrolase-like protein isoform X1

    Conserved Domains (1) summary
    PLN02469
    Location:1272
    PLN02469; hydroxyacylglutathione hydrolase
  3. XM_063270094.1XP_063126164.1  hydroxyacylglutathione hydrolase-like protein isoform X2

    UniProtKB/TrEMBL
    D4A2F7
  4. XM_006246065.3XP_006246127.1  hydroxyacylglutathione hydrolase-like protein isoform X3

    Conserved Domains (2) summary
    pfam16123
    Location:126204
    HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    cl23716
    Location:2125
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001013114.1: Suppressed sequence

    Description
    NM_001013114.1: This RefSeq was temporarily suppressed because the CDS was partial and based on aberrant transcript data.