otpb orthopedia homeobox b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: otpbprovided by ZNC
Official Full Name: orthopedia homeobox bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990708-7
See related: Ensembl:ENSDARG00000058379 AllianceGenome:ZFIN:ZDB-GENE-990708-7
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: otp; otp1; cb977
Summary: Predicted to enable DNA binding activity. Involved in myelination. Acts upstream of or within forebrain neuron development; hypothalamus development; and mammillary body development. Predicted to be located in nucleus. Is expressed in several structures, including brain; gonad; neural keel; neural plate; and neurons. Orthologous to human OTP (orthopedia homeobox). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (51615990..51619374, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (50969399..50972786, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings reveal a new role for Otp in controlling developmental neuropeptide balance in a discrete oxytocinergic hypothalamic circuit whose disrupted development affects social behavior.
Title: Homeodomain protein Otp affects developmental neuropeptide switching in oxytocin neurons associated with a long-term effect on social behavior.
Identification of an evolutionarily conserved vertebrate OTP enhancer module with activity in a restricted area of the forebrain.
Title: A vertebrate-conserved cis-regulatory module for targeted expression in the main hypothalamic regulatory region for the stress response.
These observations suggest that the requirement for otpa and otpb function during development of the larval diencephalon is partially redundant.
Title: Orthopedia transcription factor otpa and otpb paralogous genes function during dopaminergic and neuroendocrine cell specification in larval zebrafish.
Results describe the ontogeny of vasotocin-expressing cells in zebrafish, and the selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area.
Title: Ontogeny of vasotocin-expressing cells in zebrafish: selective requirement for the transcriptional regulators orthopedia and single-minded 1 in the preoptic area.
Otp1 transcription factor is important for regulation of diencephalon development and early neuronal progenitors.
Title: Differential regulation of the zebrafish orthopedia 1 gene during fate determination of diencephalic neurons.
Orthopedia is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system.
Title: Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within forebrain neuron development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hypothalamus development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within mammillary body development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in myelination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: homeobox protein orthopedia B

Names: orthopedia homolog b; orthopedia protein; otp a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423850.1 → NP_001410779.1 homeobox protein orthopedia B isoform 2

Status: VALIDATED

Source sequence(s)

BX470070

UniProtKB/Swiss-Prot

Q6DGH9, Q9W7M5

UniProtKB/TrEMBL

B0S6A5
NM_131100.2 → NP_571175.1 homeobox protein orthopedia B isoform 1

See identical proteins and their annotated locations for NP_571175.1

Status: VALIDATED

Source sequence(s)

BX470070

UniProtKB/Swiss-Prot

Q6DGH9

Related

ENSDARP00000122985.1, ENSDART00000134606.3

Conserved Domains (2) summary

pfam00046
Location:115 → 163

Homeobox; Homeobox domain

pfam03826
Location:305 → 322

OAR; OAR domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

51615990..51619374 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005165505.3 → XP_005165562.1 homeobox protein orthopedia B isoform X1

UniProtKB/Swiss-Prot

Q6DGH9

UniProtKB/TrEMBL

B0S6A5

Related

ENSDARP00000075692.4, ENSDART00000081249.5

Conserved Domains (2) summary

pfam00046
Location:102 → 150

Homeobox; Homeobox domain

pfam03826
Location:292 → 309

OAR; OAR domain