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Mmp28 matrix metallopeptidase 28 [ Rattus norvegicus (Norway rat) ]

Gene ID: 303384, updated on 30-Sep-2021

Summary

Symbol
Mmp28provided by RGD
Full Name
matrix metallopeptidase 28provided by RGD
Primary source
RGD:1311573
See related
EnsemblRapid:ENSRNOG00000047940
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Adrenal (RPKM 41.7), Lung (RPKM 38.5) and 9 other tissues See more
Orthologs
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Genomic context

See Mmp28 in Genome Data Viewer
Location:
10q26
Exon count:
8
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68243748..68264728, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70660691..70681672, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene growth arrest-specific 2 like 2 Neighboring gene hypothetical protein LOC689039 Neighboring gene uncharacterized LOC120095158 Neighboring gene TATA-box binding protein associated factor 15 Neighboring gene HEAT repeat containing 9

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
matrix metalloproteinase-28
Names
matrix metallopeptidase 28 (epilysin)
matrix metalloproteinase 28 (epilysin)
matrix metalloproteinase-28-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001079888.1NP_001073357.1  matrix metalloproteinase-28 precursor

    See identical proteins and their annotated locations for NP_001073357.1

    Status: PROVISIONAL

    Source sequence(s)
    EF121988
    UniProtKB/TrEMBL
    A1EC81
    Related
    ENSRNOP00000013836.4, ENSRNOT00000013836.5
    Conserved Domains (4) summary
    cd00094
    Location:321508
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:129284
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:129284
    Peptidase_M10; Matrixin
    pfam01471
    Location:3486
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    68243748..68264728 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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