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Ripk4 receptor-interacting serine-threonine kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304053, updated on 5-Mar-2024

Summary

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Official Symbol
Ripk4provided by RGD
Official Full Name
receptor-interacting serine-threonine kinase 4provided by RGD
Primary source
RGD:1311691
See related
Ensembl:ENSRNOG00000001618 AllianceGenome:RGD:1311691
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP binding activity and protein kinase activity. Predicted to be involved in morphogenesis of an epithelium and positive regulation of NF-kappaB transcription factor activity. Predicted to be located in cytoplasm. Orthologous to human RIPK4 (receptor interacting serine/threonine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 71.9), Liver (RPKM 58.9) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
11q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50591926..50614169, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (37122555..37144799, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38251991..38274234, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 1, pseudogene 1 Neighboring gene uncharacterized LOC108352390 Neighboring gene PR/SET domain 15 Neighboring gene C2 calcium-dependent domain containing 2 Neighboring gene uncharacterized LOC134480980

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus. Mitchell K, et al. Am J Hum Genet, 2012 Jan 13. PMID 22197488, Free PMC Article
  2. cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4). Bertrand MJ, et al. PLoS One, 2011. PMID 21931591, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in morphogenesis of an epithelium ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor-interacting serine/threonine-protein kinase 4
NP_001100573.1
XP_017453501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107103.1 → NP_001100573.1  receptor-interacting serine/threonine-protein kinase 4

    See identical proteins and their annotated locations for NP_001100573.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473967
    UniProtKB/TrEMBL
    A6IQH3
    Related
    ENSRNOP00000002206.2, ENSRNOT00000002206.6
    Conserved Domains (5) summary
    smart00219
    Location:26 → 279
    TyrKc; Tyrosine kinase, catalytic domain
    cd00204
    Location:600 → 725
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd14025
    Location:25 → 290
    STKc_RIP4_like; Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins
    pfam12796
    Location:610 → 701
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:605 → 636
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    50591926..50614169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598012.2 → XP_017453501.1  receptor-interacting serine/threonine-protein kinase 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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