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Gigyf1 GRB10 interacting GYF protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304378, updated on 5-Mar-2024

Summary

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Official Symbol
Gigyf1provided by RGD
Official Full Name
GRB10 interacting GYF protein 1provided by RGD
Primary source
RGD:1309933
See related
Ensembl:ENSRNOG00000001410 AllianceGenome:RGD:1309933
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Perq1
Summary
Predicted to be involved in insulin-like growth factor receptor signaling pathway. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Orthologous to human GIGYF1 (GRB10 interacting GYF protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 111.6), Kidney (RPKM 101.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gigyf1 in Genome Data Viewer
Location:
12q12
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24800996..24819719, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19166070..19181570, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22234296..22251898, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene small nuclear ribonucleoprotein Sm D1-like Neighboring gene G protein subunit beta 2 Neighboring gene POP7 homolog, ribonuclease P/MRP subunit Neighboring gene erythropoietin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. Giovannone B, et al. J Biol Chem, 2003 Aug 22. PMID 12771153
  2. Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis. Ajiro M, et al. Int J Oncol, 2010 Nov. PMID 20878056
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in insulin-like growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
GRB10-interacting GYF protein 1
Names
PERQ amino acid rich, with GYF domain 1
PERQ amino acid-rich with GYF domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107133.1 → NP_001100603.1  GRB10-interacting GYF protein 1

    See identical proteins and their annotated locations for NP_001100603.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A6J025, D3ZQJ3
    Related
    ENSRNOP00000001912.4, ENSRNOT00000001912.6
    Conserved Domains (1) summary
    cd00072
    Location:475 → 528
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    24800996..24819719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039089418.2 → XP_038945346.1  GRB10-interacting GYF protein 1 isoform X5

    Conserved Domains (2) summary
    PRK12678
    Location:106 → 289
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:462 → 515
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  2. XM_039089417.2 → XP_038945345.1  GRB10-interacting GYF protein 1 isoform X3

    Conserved Domains (2) summary
    PRK12678
    Location:112 → 265
    PRK12678; transcription termination factor Rho; Provisional
    cd00072
    Location:474 → 527
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  3. XM_006249153.4 → XP_006249215.1  GRB10-interacting GYF protein 1 isoform X2

    Conserved Domains (1) summary
    cd00072
    Location:474 → 527
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

  4. XM_063271282.1 → XP_063127352.1  GRB10-interacting GYF protein 1 isoform X4

  5. XM_017598327.3 → XP_017453816.1  GRB10-interacting GYF protein 1 isoform X1

    UniProtKB/TrEMBL
    A6J025, D3ZQJ3
    Conserved Domains (1) summary
    cd00072
    Location:475 → 528
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
Nucleotide Protein Strain
Heading Accession and Version

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