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Tbx5 T-box transcription factor 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304514, updated on 30-Sep-2021

Summary

Official Symbol
Tbx5provided by RGD
Official Full Name
T-box transcription factor 5provided by RGD
Primary source
RGD:1305702
See related
EnsemblRapid:ENSRNOG00000001399
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Heart (RPKM 79.6) and Lung (RPKM 69.1) See more
Orthologs
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Genomic context

See Tbx5 in Genome Data Viewer
Location:
12q16
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (36686344..36739253, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (42059688..42148226)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352451 Neighboring gene uncharacterized LOC120095982 Neighboring gene uncharacterized LOC102549962 Neighboring gene T-box transcription factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in animal organ development ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within atrial septum development ISO
Inferred from Sequence Orthology
more info
 
involved_in atrial septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within atrial septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular bundle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in atrioventricular bundle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular node cell development IEA
Inferred from Electronic Annotation
more info
 
involved_in atrioventricular node cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular node cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
involved_in atrioventricular node cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
involved_in atrioventricular valve morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within atrioventricular valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in bundle of His cell to Purkinje myocyte communication by electrical coupling IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within bundle of His cell to Purkinje myocyte communication by electrical coupling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within bundle of His development ISO
Inferred from Sequence Orthology
more info
 
involved_in bundle of His development ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac left ventricle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cardiac left ventricle formation IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac left ventricle formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell signaling involved in cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell-cell signaling involved in cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic forelimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic forelimb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in embryonic limb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocardial cushion development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endocardial cushion development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development ISO
Inferred from Sequence Orthology
more info
 
involved_in heart development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lung development ISO
Inferred from Sequence Orthology
more info
 
involved_in morphogenesis of an epithelium IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within morphogenesis of an epithelium ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pattern specification process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in pattern specification process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pattern specification process ISO
Inferred from Sequence Orthology
more info
 
involved_in pericardium development IEA
Inferred from Electronic Annotation
more info
 
involved_in pericardium development ISO
Inferred from Sequence Orthology
more info
 
involved_in pericardium development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac conduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of cardiac conduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardioblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardioblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cardioblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gap junction assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of gap junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of secondary heart field cardioblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of atrial cardiac muscle cell membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of atrial cardiac muscle cell membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in transdifferentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
involved_in ventricular septum development IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular septum development ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-DNA complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-DNA complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-box transcription factor TBX5
Names
T-box 5
T-box protein 5

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009964.1NP_001009964.1  T-box transcription factor TBX5

    See identical proteins and their annotated locations for NP_001009964.1

    Status: PROVISIONAL

    Source sequence(s)
    AY859491
    UniProtKB/Swiss-Prot
    Q5I2P1
    Related
    ENSRNOP00000001893.4, ENSRNOT00000001893.6
    Conserved Domains (1) summary
    cd00182
    Location:53241
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    36686344..36739253 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769230.3XP_008767452.1  T-box transcription factor TBX5 isoform X1

    See identical proteins and their annotated locations for XP_008767452.1

    UniProtKB/TrEMBL
    G3V657
    Conserved Domains (1) summary
    cd20189
    Location:54238
    T-box_TBX4_5-like; DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins
  2. XM_039089491.1XP_038945419.1  T-box transcription factor TBX5 isoform X1

    Conserved Domains (1) summary
    cd20189
    Location:54238
    T-box_TBX4_5-like; DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins
  3. XM_017598339.2XP_017453828.1  T-box transcription factor TBX5 isoform X1

    UniProtKB/TrEMBL
    G3V657
    Conserved Domains (1) summary
    cd20189
    Location:54238
    T-box_TBX4_5-like; DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins
  4. XM_006249390.4XP_006249452.1  T-box transcription factor TBX5 isoform X1

    See identical proteins and their annotated locations for XP_006249452.1

    UniProtKB/TrEMBL
    G3V657
    Conserved Domains (1) summary
    cd20189
    Location:54238
    T-box_TBX4_5-like; DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins
  5. XM_006249387.4XP_006249449.1  T-box transcription factor TBX5 isoform X1

    See identical proteins and their annotated locations for XP_006249449.1

    UniProtKB/TrEMBL
    G3V657
    Conserved Domains (1) summary
    cd20189
    Location:54238
    T-box_TBX4_5-like; DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins
  6. XM_006249391.4XP_006249453.1  T-box transcription factor TBX5 isoform X1

    See identical proteins and their annotated locations for XP_006249453.1

    UniProtKB/TrEMBL
    G3V657
    Conserved Domains (1) summary
    cd20189
    Location:54238
    T-box_TBX4_5-like; DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins
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