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Bicdl1 BICD family like cargo adaptor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304537, updated on 13-Apr-2024

Summary

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Official Symbol
Bicdl1provided by RGD
Official Full Name
BICD family like cargo adaptor 1provided by RGD
Primary source
RGD:1310292
See related
Ensembl:ENSRNOG00000056955 AllianceGenome:RGD:1310292
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccdc64; RGD1310292
Summary
Predicted to enable dynactin binding activity and small GTPase binding activity. Predicted to be involved in Golgi to secretory granule transport and neuron projection development. Predicted to be located in centrosome. Orthologous to human BICDL1 (BICD family like cargo adaptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 77.2), Brain (RPKM 76.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46537525..46626876)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (40878190..41001152)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (46615597..46703287)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547619 Neighboring gene transfer RNA proline (anticodon AGG) 85 Neighboring gene RAB35, member RAS oncogene family Neighboring gene uncharacterized LOC120096002 Neighboring gene GCN1 activator of EIF2AK4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis. Schlager MA, et al. EMBO J, 2010 May 19. PMID 20360680, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables dynactin binding ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Golgi to secretory granule transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BICD family-like cargo adapter 1
Names
bicaudal D-related protein 1
coiled-coil domain containing 64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191667.2 → NP_001178596.1  BICD family-like cargo adapter 1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6GEA9, A6J1S4
    Related
    ENSRNOP00000086697.1, ENSRNOT00000119377.1
    Conserved Domains (2) summary
    pfam01665
    Location:100 → 240
    Rota_NSP3; Rotavirus non-structural protein NSP3
    pfam14988
    Location:121 → 297
    DUF4515; Domain of unknown function (DUF4515)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    46537525..46626876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769234.4 → XP_008767456.1  BICD family-like cargo adapter 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JY46, A0A0G2KAQ3
    Related
    ENSRNOP00000075484.2
    Conserved Domains (2) summary
    pfam01665
    Location:100 → 240
    Rota_NSP3; Rotavirus non-structural protein NSP3
    pfam14988
    Location:121 → 297
    DUF4515; Domain of unknown function (DUF4515)

  2. XM_063271347.1 → XP_063127417.1  BICD family-like cargo adapter 1 isoform X2

  3. XM_063271348.1 → XP_063127418.1  BICD family-like cargo adapter 1 isoform X3

RNA

  1. XR_010056386.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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