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Coq5 coenzyme Q5, methyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 304542, updated on 11-Apr-2024

Summary

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Official Symbol
Coq5provided by RGD
Official Full Name
coenzyme Q5, methyltransferaseprovided by RGD
Primary source
RGD:1310857
See related
Ensembl:ENSRNOG00000001171 AllianceGenome:RGD:1310857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310857
Summary
Predicted to enable 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity. Predicted to be involved in methylation and ubiquinone biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be part of protein-containing complex. Predicted to colocalize with mitochondrial inner membrane. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 192.1), Adrenal (RPKM 144.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (46977632..46994575, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (41316922..41333855, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (47078753..47095438, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene serine and arginine rich splicing factor 9 Neighboring gene dynein light chain LC8-type 1 Neighboring gene uncharacterized LOC120096006 Neighboring gene ring finger protein 10 Neighboring gene POP5 homolog, ribonuclease P/MRP subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis. Nguyen TP, et al. Biochim Biophys Acta, 2014 Nov. PMID 25152161, Free PMC Article
  2. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
  3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112711

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquinone biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extrinsic component of mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
part_of ubiquinone biosynthesis complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial
Names
coenzyme Q5 homolog, methyltransferase
ubiquinone biosynthesis methyltransferase COQ5, mitochondrial
NP_001034111.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039022.1 → NP_001034111.1  2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001034111.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098719
    UniProtKB/Swiss-Prot
    Q4G064
    Related
    ENSRNOP00000001547.3, ENSRNOT00000001546.7
    Conserved Domains (1) summary
    PRK00216
    Location:56 → 327
    ubiE; bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    46977632..46994575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_005491629.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4G064.1 GenPept UniProtKB/Swiss-Prot:Q4G064

Gene LinkOut

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