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Ttc28 tetratricopeptide repeat domain 28 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304558, updated on 3-Apr-2024

Summary

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Official Symbol
Ttc28provided by RGD
Official Full Name
tetratricopeptide repeat domain 28provided by RGD
Primary source
RGD:1594541
See related
Ensembl:ENSRNOG00000032590 AllianceGenome:RGD:1594541
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable kinase binding activity. Predicted to be involved in regulation of mitotic cell cycle. Predicted to be located in midbody. Orthologous to human TTC28 (tetratricopeptide repeat domain 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 47.4), Lung (RPKM 46.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q16
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (51002816..51443461, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (45342986..45783968, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (51385808..51840710, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481215 Neighboring gene phosphatidylinositol transfer protein, beta Neighboring gene uncharacterized LOC134481214 Neighboring gene uncharacterized LOC102554233 Neighboring gene uncharacterized LOC102553561 Neighboring gene uncharacterized LOC120096015 Neighboring gene checkpoint kinase 2 Neighboring gene HscB mitochondrial iron-sulfur cluster co-chaperone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel big protein TPRBK possessing 25 units of TPR motif is essential for the progress of mitosis and cytokinesis. Izumiyama T, et al. Gene, 2012 Dec 15. PMID 23036704
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in midbody ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tetratricopeptide repeat protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    51002816..51443461 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271797.1 → XP_063127867.1  tetratricopeptide repeat protein 28 isoform X3

  2. XM_063271796.1 → XP_063127866.1  tetratricopeptide repeat protein 28 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZRJ0

  3. XM_006249584.5 → XP_006249646.1  tetratricopeptide repeat protein 28 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBH2, A0A8I6ASI5
    Related
    ENSRNOP00000076352.1
    Conserved Domains (7) summary
    smart00028
    Location:388 → 420
    TPR; Tetratricopeptide repeats
    COG0457
    Location:688 → 989
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:85 → 115
    TPR; TPR repeat [structural motif]
    pfam12770
    Location:1384 → 1707
    CHAT; CHAT domain
    pfam13176
    Location:953 → 988
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:88 → 151
    TPR_11; TPR repeat
    pfam13424
    Location:309 → 380
    TPR_12; Tetratricopeptide repeat

  4. XM_039090202.2 → XP_038946130.1  tetratricopeptide repeat protein 28 isoform X5

    Conserved Domains (5) summary
    TIGR02917
    Location:174 → 980
    PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
    sd00006
    Location:424 → 452
    TPR; TPR repeat [structural motif]
    pfam05109
    Location:1891 → 2183
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam13424
    Location:104 → 176
    TPR_12; Tetratricopeptide repeat
    pfam12770
    Location:1220 → 1543
    CHAT; CHAT domain

  5. XM_006249585.5 → XP_006249647.1  tetratricopeptide repeat protein 28 isoform X4

    UniProtKB/TrEMBL
    D3ZXP1
    Related
    ENSRNOP00000044499.6
    Conserved Domains (7) summary
    smart00028
    Location:276 → 308
    TPR; Tetratricopeptide repeats
    COG0457
    Location:576 → 877
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:476 → 504
    TPR; TPR repeat [structural motif]
    pfam12770
    Location:1272 → 1595
    CHAT; CHAT domain
    pfam13176
    Location:841 → 876
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:960 → 1028
    TPR_11; TPR repeat
    pfam13424
    Location:197 → 268
    TPR_12; Tetratricopeptide repeat
Nucleotide Protein Strain
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