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Orai2 ORAI calcium release-activated calcium modulator 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 304592, updated on 13-Apr-2024

Summary

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Official Symbol
Orai2provided by RGD
Official Full Name
ORAI calcium release-activated calcium modulator 2provided by RGD
Primary source
RGD:1310213
See related
Ensembl:ENSRNOG00000001427 AllianceGenome:RGD:1310213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310213
Summary
Predicted to enable store-operated calcium channel activity. Predicted to be involved in store-operated calcium entry. Located in growth cone. Orthologous to human ORAI2 (ORAI calcium release-activated calcium modulator 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 117.8), Spleen (RPKM 69.5) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Orai2 in Genome Data Viewer
Location:
12q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (26136922..26157041)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (20500308..20520428)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23544483..23564602)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481276 Neighboring gene PRKR interacting protein 1 Neighboring gene uncharacterized LOC134481277 Neighboring gene alkB homolog 4, lysine demethylase Neighboring gene leucine-rich repeats and WD repeat domain containing 1 Neighboring gene RNA polymerase II subunit J

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Orai-2 is localized on secretory granules and regulates antigen-evoked Ca²⁺ mobilization and exocytosis in mast cells. Ikeya M, et al. Biochem Biophys Res Commun, 2014 Aug 15. PMID 25044118
  2. STIM1 is necessary for store-operated calcium entry in turning growth cones. Mitchell CB, et al. J Neurochem, 2012 Sep. PMID 22712562
  3. STIM proteins: dynamic calcium signal transducers. Soboloff J, et al. Nat Rev Mol Cell Biol, 2012 Sep. PMID 22914293, Free PMC Article
  4. Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry. Takahashi Y, et al. Biochem Biophys Res Commun, 2007 Apr 27. PMID 17343823
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Orai-2 is localized on secretory granules in mast cells.Orai-2 regulates degranulation by affecting Ca release from Ca store.
    Title: Orai-2 is localized on secretory granules and regulates antigen-evoked Ca²⁺ mobilization and exocytosis in mast cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables store-operated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables store-operated calcium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in store-operated calcium entry IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in store-operated calcium entry ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein orai-2
Names
CAP-binding protein complex interacting protein 2
calcium release-activated calcium modulator 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170403.1 → NP_001163874.1  protein orai-2

    See identical proteins and their annotated locations for NP_001163874.1

    Status: VALIDATED

    Source sequence(s)
    BC158835, EU644750, JAXUCZ010000012
    UniProtKB/TrEMBL
    B2ZDP9, F7EZ46
    Related
    ENSRNOP00000085810.1, ENSRNOT00000110615.1
    Conserved Domains (1) summary
    pfam07856
    Location:110 → 287
    Orai-1; Mediator of CRAC channel activity

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    26136922..26157041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017598356.2 → XP_017453845.1  protein orai-2 isoform X1

    Conserved Domains (1) summary
    pfam07856
    Location:1 → 147
    Orai-1; Mediator of CRAC channel activity

  2. XM_039089527.2 → XP_038945455.1  protein orai-2 isoform X1

    Conserved Domains (1) summary
    pfam07856
    Location:1 → 147
    Orai-1; Mediator of CRAC channel activity
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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