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Utp25 UTP25 small subunit processome component [ Rattus norvegicus (Norway rat) ]

Gene ID: 305076, updated on 5-Mar-2024

Summary

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Official Symbol
Utp25provided by RGD
Official Full Name
UTP25 small subunit processome componentprovided by RGD
Primary source
RGD:1359148
See related
Ensembl:ENSRNOG00000004789 AllianceGenome:RGD:1359148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Def; Diexf
Summary
Predicted to enable U3 snoRNA binding activity and rRNA binding activity. Predicted to be involved in several processes, including maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); protein destabilization; and protein localization to nucleolus. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human UTP25 (UTP25 small subunit processor component). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 68.6), Spleen (RPKM 64.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Utp25 in Genome Data Viewer
Location:
13q27
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (107159092..107180361, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (104630390..104651681, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (111828052..111849654, complement)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481546 Neighboring gene uncharacterized LOC120096359 Neighboring gene uncharacterized LOC120096360 Neighboring gene interferon regulatory factor 6 Neighboring gene similar to human chromosome 1 open reading frame 74 Neighboring gene TRAF3 interacting protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53. Aryal NK, et al. Oncotarget, 2017 Nov 28. PMID 29262616, Free PMC Article
  2. Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Tao T, et al. Cell Res, 2013 May. PMID 23357851, Free PMC Article
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables U3 snoRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in embryonic organ development ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic organ development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein destabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to nucleolus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
U3 small nucleolar RNA-associated protein 25 homolog
Names
UTP25, small subunit processor component
novel putative protein similar to YIL091C yeast hypothetical 84 kD protein from SGA1-KTR7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013986.2 → NP_001014008.1  U3 small nucleolar RNA-associated protein 25 homolog

    See identical proteins and their annotated locations for NP_001014008.1

    Status: VALIDATED

    Source sequence(s)
    BC087114, CB569988
    UniProtKB/Swiss-Prot
    Q5M9G7
    UniProtKB/TrEMBL
    A6JH19
    Related
    ENSRNOP00000006395.4, ENSRNOT00000006395.7
    Conserved Domains (1) summary
    pfam06862
    Location:283 → 758
    UTP25; Utp25, U3 small nucleolar RNA-associated SSU processome protein 25

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    107159092..107180361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272402.1 → XP_063128472.1  U3 small nucleolar RNA-associated protein 25 homolog isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5M9G7.1 GenPept UniProtKB/Swiss-Prot:Q5M9G7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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