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Art3 ADP-ribosyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305235, updated on 3-Apr-2024

Summary

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Official Symbol
Art3provided by RGD
Official Full Name
ADP-ribosyltransferase 3provided by RGD
Primary source
RGD:628833
See related
Ensembl:ENSRNOG00000002256 AllianceGenome:RGD:628833
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NAD+ ADP-ribosyltransferase activity. Predicted to be involved in peptidyl-arginine ADP-ribosylation. Predicted to be integral component of membrane. Orthologous to human ART3 (ADP-ribosyltransferase 3 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1090.7), Muscle (RPKM 1061.5) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Art3 in Genome Data Viewer
Location:
14p22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (15921540..16003764, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (15637230..15719442, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17143037..17225389, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene scavenger receptor class B, member 2 Neighboring gene small Cajal body-specific RNA 4 Neighboring gene nucleoporin 54 Neighboring gene CWF19 like cell cycle control factor 1, pseudogene 1 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene SDA1 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury. Shi W, et al. J Mol Histol, 2012 Feb. PMID 22037978
  2. ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks. Wang B, et al. J Biol Chem, 1997 Jul 11. PMID 9211900
  3. Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. Koch-Nolte F, et al. Genomics, 1997 Feb 1. PMID 9119374
  4. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ART3 may play important roles in CNS pathophysiology after traumatic brain injury (TBI).
    Title: The expression pattern of ADP-ribosyltransferase 3 in rat traumatic brain injury.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ecto-ADP-ribosyltransferase 3
NP_001012034.1
XP_006250789.3
XP_006250790.2
XP_038947782.1
XP_038947783.1
XP_038947784.1
XP_038947785.1
XP_038947786.1
XP_063129126.1
XP_063129127.1
XP_063129128.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012034.1 → NP_001012034.1  ecto-ADP-ribosyltransferase 3 precursor

    See identical proteins and their annotated locations for NP_001012034.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079018
    UniProtKB/TrEMBL
    A0A8I6GLM8, Q6AYJ9
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    15921540..16003764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039091856.2 → XP_038947784.1  ecto-ADP-ribosyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLM8
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  2. XM_039091857.2 → XP_038947785.1  ecto-ADP-ribosyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLM8
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  3. XM_006250727.4 → XP_006250789.3  ecto-ADP-ribosyltransferase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A9H4

  4. XM_006250728.4 → XP_006250790.2  ecto-ADP-ribosyltransferase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8I6GLM8, F7EXX0
    Related
    ENSRNOP00000039770.3

  5. XM_039091854.2 → XP_038947782.1  ecto-ADP-ribosyltransferase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLM8
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  6. XM_063273056.1 → XP_063129126.1  ecto-ADP-ribosyltransferase 3 isoform X5

    UniProtKB/TrEMBL
    A0A0G2K8S9

  7. XM_039091855.2 → XP_038947783.1  ecto-ADP-ribosyltransferase 3 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GLM8
    Related
    ENSRNOP00000074723.2
    Conserved Domains (1) summary
    cl00173
    Location:46 → 268
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...

  8. XM_063273058.1 → XP_063129128.1  ecto-ADP-ribosyltransferase 3 isoform X7

  9. XM_063273057.1 → XP_063129127.1  ecto-ADP-ribosyltransferase 3 isoform X6

  10. XM_039091858.2 → XP_038947786.1  ecto-ADP-ribosyltransferase 3 isoform X8

    UniProtKB/TrEMBL
    A6KK90
    Conserved Domains (1) summary
    cl00173
    Location:29 → 251
    VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
Nucleotide Protein Strain
Heading Accession and Version

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