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Rassf6 Ras association domain family member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 305251, updated on 3-Apr-2024

Summary

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Official Symbol
Rassf6provided by RGD
Official Full Name
Ras association domain family member 6provided by RGD
Primary source
RGD:1566082
See related
Ensembl:ENSRNOG00000002866 AllianceGenome:RGD:1566082
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in regulation of apoptotic process and signal transduction. Predicted to act upstream of or within positive regulation of apoptotic process. Orthologous to human RASSF6 (Ras association domain family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 55.0), Kidney (RPKM 51.4) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
14p22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (17717505..17757507)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (17433328..17473565)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18983852..19023921)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093066 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120096582 Neighboring gene albumin superfamily member 1 Neighboring gene uncharacterized LOC134481727 Neighboring gene afamin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The RASSF6 tumor suppressor protein regulates apoptosis and the cell cycle via MDM2 protein and p53 protein. Iwasa H, et al. J Biol Chem, 2013 Oct 18. PMID 24003224, Free PMC Article
  2. RASSF6 is a novel member of the RASSF family of tumor suppressors. Allen NP, et al. Oncogene, 2007 Sep 13. PMID 17404571
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC114410

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras association domain-containing protein 6
Names
Ras association (RalGDS/AF-6) domain family member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025671.2 → NP_001020842.1  ras association domain-containing protein 6

    See identical proteins and their annotated locations for NP_001020842.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q4QR82
    Related
    ENSRNOP00000003836.5, ENSRNOT00000003836.7
    Conserved Domains (2) summary
    pfam16517
    Location:291 → 329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:191 → 277
    UBQ; Ubiquitin-like proteins

  2. NM_001428978.1 → NP_001415907.1  ras association domain-containing protein 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

  3. NM_001428979.1 → NP_001415908.1  ras association domain-containing protein 6

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000014

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    17717505..17757507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250745.5 → XP_006250807.1  ras association domain-containing protein 6 isoform X2

    UniProtKB/Swiss-Prot
    Q4QR82
    Conserved Domains (2) summary
    pfam16517
    Location:291 → 329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:191 → 277
    UBQ; Ubiquitin-like proteins

  2. XM_006250747.5 → XP_006250809.1  ras association domain-containing protein 6 isoform X2

    UniProtKB/Swiss-Prot
    Q4QR82
    Conserved Domains (2) summary
    pfam16517
    Location:291 → 329
    Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    cl00155
    Location:191 → 277
    UBQ; Ubiquitin-like proteins

  3. XM_039091870.2 → XP_038947798.2  ras association domain-containing protein 6 isoform X3

  4. XM_008770036.3 → XP_008768258.2  ras association domain-containing protein 6 isoform X1

  5. XM_039091869.2 → XP_038947797.1  ras association domain-containing protein 6 isoform X4

    Conserved Domains (1) summary
    cl28922
    Location:94 → 180
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4QR82.1 GenPept UniProtKB/Swiss-Prot:Q4QR82

Gene LinkOut

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