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Rab2b RAB2B, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 305853, updated on 11-Apr-2024

Summary

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Official Symbol
Rab2bprovided by RGD
Official Full Name
RAB2B, member RAS oncogene familyprovided by RGD
Primary source
RGD:1309117
See related
Ensembl:ENSRNOG00000012488 AllianceGenome:RGD:1309117
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in positive regulation of exocytosis. Located in presynapse. Orthologous to human RAB2B (RAB2B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 97.1), Kidney (RPKM 81.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
15p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27441860..27462479, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24968364..24988990, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28675504..28696192, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene SPT16 homolog, facilitates chromatin remodeling subunit Neighboring gene ribosomal protein L9, pseudogene 29 Neighboring gene chromodomain helicase DNA binding protein 8 Neighboring gene small nucleolar RNA, C/D box 8 Neighboring gene U6 spliceosomal RNA Neighboring gene Small nucleolar RNA SNORA72 Neighboring gene TOX high mobility group box family member 4 Neighboring gene methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rab27a and Rab27b control different steps of the exosome secretion pathway. Ostrowski M, et al. Nat Cell Biol, 2010 Jan. PMID 19966785
  2. Quantitative analysis of synaptic vesicle Rabs uncovers distinct yet overlapping roles for Rab3a and Rab27b in Ca2+-triggered exocytosis. Pavlos NJ, et al. J Neurosci, 2010 Oct 6. PMID 20926670, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC125131

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in macroautophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in autophagosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein Rab-2B
NP_001032734.1
XP_038949207.1
XP_038949210.1
XP_063130300.1
XP_063130301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037645.1 → NP_001032734.1  ras-related protein Rab-2B

    See identical proteins and their annotated locations for NP_001032734.1

    Status: PROVISIONAL

    Source sequence(s)
    BC107443
    UniProtKB/TrEMBL
    A0A8I6G3N4, A6KEG9, A6KEH0, Q3B7V5
    Related
    ENSRNOP00000057211.2, ENSRNOT00000060467.5
    Conserved Domains (1) summary
    PLN03108
    Location:1 → 215
    PLN03108; Rab family protein; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    27441860..27462479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093282.2 → XP_038949210.1  ras-related protein Rab-2B isoform X4

    Conserved Domains (1) summary
    PLN03108
    Location:1 → 119
    PLN03108; Rab family protein; Provisional

  2. XM_039093279.2 → XP_038949207.1  ras-related protein Rab-2B isoform X3

    UniProtKB/TrEMBL
    A0A8I6A284
    Related
    ENSRNOP00000084964.1
    Conserved Domains (1) summary
    cl38936
    Location:3 → 120
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_063274231.1 → XP_063130301.1  ras-related protein Rab-2B isoform X2

  4. XM_063274230.1 → XP_063130300.1  ras-related protein Rab-2B isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKQ1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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