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Spock3 SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306404, updated on 5-Jun-2021

Summary

Official Symbol
Spock3provided by RGD
Official Full Name
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3provided by RGD
Primary source
RGD:1305672
See related
Ensembl:ENSRNOG00000029903
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Brain (RPKM 332.2) and Adrenal (RPKM 19.5) See more
Orthologs
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Genomic context

See Spock3 in Genome Data Viewer
Location:
16p13
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (26382895..26815943, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (28372067..28716762, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene similar to Ab1-351 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein S3a-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables glycosaminoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables metalloendopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
testican-3
Names
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107310.1NP_001100780.1  testican-3 precursor

    See identical proteins and their annotated locations for NP_001100780.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474045
    Conserved Domains (4) summary
    smart00280
    Location:143186
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:319383
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:203320
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:202309
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    26382895..26815943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600103.2XP_017455592.1  testican-3 isoform X2

  2. XM_017600102.2XP_017455591.1  testican-3 isoform X1

  3. XM_017600104.2XP_017455593.1  testican-3 isoform X3

    Conserved Domains (4) summary
    smart00280
    Location:140183
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:316380
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:200317
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:199306
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
  4. XM_017600105.2XP_017455594.1  testican-3 isoform X4

    UniProtKB/TrEMBL
    D3ZUT1
    Related
    ENSRNOP00000056503.4
  5. XM_008771117.3XP_008769339.1  testican-3 isoform X3

    Conserved Domains (4) summary
    smart00280
    Location:140183
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:316380
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:200317
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:199306
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
  6. XM_039094497.1XP_038950425.1  testican-3 isoform X5

    Conserved Domains (2) summary
    cd00191
    Location:126190
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd16239
    Location:11123
    EFh_SPARC_TICN3; EF-hand, extracellular calcium-binding (EC) motif, found in testican-3 (TICN3)
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