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Sh3rf1 SH3 domain containing ring finger 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306417, updated on 6-May-2021

Summary

Official Symbol
Sh3rf1provided by RGD
Official Full Name
SH3 domain containing ring finger 1provided by RGD
Primary source
RGD:735154
See related
Ensembl:ENSRNOG00000010358
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Posh; Sh3md2
Summary
putative scaffolding protein; involved in Rac-induced signal transduction pathways [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 129.4), Lung (RPKM 73.3) and 9 other tissues See more
Orthologs
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Genomic context

See Sh3rf1 in Genome Data Viewer
Location:
16p12
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (28735522..28901690, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (32062425..32227526, complement)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene palladin, cytoskeletal associated protein Neighboring gene uncharacterized LOC120097383 Neighboring gene U6 spliceosomal RNA Neighboring gene carbonyl reductase 4 Neighboring gene uncharacterized LOC102547442 Neighboring gene NIMA-related kinase 1 Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene chloride voltage-gated channel 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables MAP-kinase scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase SH3RF1
Names
RING-type E3 ubiquitin transferase SH3RF1
SH3 domain-containing RING finger protein 1
SH3 multiple domains protein 2
plenty of SH3s
putative E3 ubiquitin-protein ligase SH3RF1
putative scaffolding protein POSH
NP_942059.1
XP_017455595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198764.1NP_942059.1  E3 ubiquitin-protein ligase SH3RF1

    See identical proteins and their annotated locations for NP_942059.1

    Status: PROVISIONAL

    Source sequence(s)
    AF515735
    UniProtKB/Swiss-Prot
    Q71F54
    Conserved Domains (4) summary
    cd11785
    Location:839893
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11930
    Location:200254
    SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    cd00162
    Location:1156
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl17036
    Location:137190
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    28735522..28901690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600106.2XP_017455595.1  E3 ubiquitin-protein ligase SH3RF1 isoform X1

    UniProtKB/Swiss-Prot
    Q71F54
    Related
    ENSRNOP00000013815.1
    Conserved Domains (4) summary
    cd11785
    Location:839893
    SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
    cd11930
    Location:200254
    SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
    cd00162
    Location:1156
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl17036
    Location:137190
    SH3; Src Homology 3 domain superfamily
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