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Mtmr7 myotubularin related protein 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306490, updated on 13-Apr-2024

Summary

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Official Symbol
Mtmr7provided by RGD
Official Full Name
myotubularin related protein 7provided by RGD
Primary source
RGD:1306608
See related
Ensembl:ENSRNOG00000011420 AllianceGenome:RGD:1306608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable inositol bisphosphate phosphatase activity and phosphatidylinositol-3-phosphatase activity. Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to act upstream of or within inositol phosphate dephosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and membrane. Orthologous to human MTMR7 (myotubularin related protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 210.5), Kidney (RPKM 48.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mtmr7 in Genome Data Viewer
Location:
16q12.1
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (58344755..58435682)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51641267..51732212)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54765214..54856255)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 25 Neighboring gene ADAM metallopeptidase domain 24 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene CCR4-NOT transcription complex, subunit 7 Neighboring gene zinc finger DHHC-type palmitoyltransferase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of myotubularin-related protein 7 and its binding partner, myotubularin-related protein 9. Mochizuki Y, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12890864, Free PMC Article
  2. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. Lorenzo O, et al. J Cell Sci, 2006 Jul 15. PMID 16787938
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables inositol bisphosphate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3,5-bisphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphatidylinositol dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myotubularin-related protein 7
NP_001100782.2
XP_038950459.1
XP_038950460.1
XP_038950461.1
XP_063131499.1
XP_063131500.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107312.3 → NP_001100782.2  myotubularin-related protein 7

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I6AEZ2, A0A8I6GGY0
    Related
    ENSRNOP00000091098.1, ENSRNOT00000105685.1
    Conserved Domains (2) summary
    cd13344
    Location:1 → 103
    PH-GRAM_MTMR7; Myotubularian (MTM) related 7 protein (MTMR7) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
    cd14583
    Location:132 → 433
    PTP-MTMR7; protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    58344755..58435682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275429.1 → XP_063131499.1  myotubularin-related protein 7 isoform X1

  2. XM_063275430.1 → XP_063131500.1  myotubularin-related protein 7 isoform X2

  3. XM_039094531.2 → XP_038950459.1  myotubularin-related protein 7 isoform X3

    UniProtKB/TrEMBL
    A6JPV0
    Conserved Domains (1) summary
    cl28904
    Location:5 → 291
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_039094532.2 → XP_038950460.1  myotubularin-related protein 7 isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:1 → 212
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. XM_039094533.2 → XP_038950461.1  myotubularin-related protein 7 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:17 → 205
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version

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