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Proz protein Z, vitamin K-dependent plasma glycoprotein [ Rattus norvegicus (Norway rat) ]

Gene ID: 306608, updated on 13-Apr-2024

Summary

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Official Symbol
Prozprovided by RGD
Official Full Name
protein Z, vitamin K-dependent plasma glycoproteinprovided by RGD
Primary source
RGD:1308666
See related
Ensembl:ENSRNOG00000019700 AllianceGenome:RGD:1308666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity and serine-type endopeptidase activity. Predicted to be involved in blood coagulation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 974.3) and Kidney (RPKM 114.1) See more
Orthologs
human mouse all
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Genomic context

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Location:
16q12.5
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (83150104..83165688, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76450013..76463558, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81784348..81797889, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene cullin 4A Neighboring gene PCI domain containing 2 Neighboring gene uncharacterized LOC134482531 Neighboring gene small ribosomal subunit protein eS19-like Neighboring gene coagulation factor X Neighboring gene coagulation factor VII

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein Z gene polymorphisms, protein Z concentrations, and ischemic stroke. Staton J, et al. Stroke, 2005 Jun. PMID 15879328
  2. A common polymorphism of the protein Z gene is associated with protein Z plasma levels and with risk of cerebral ischemia in the young. Lichy C, et al. Stroke, 2004 Jan. PMID 14671240
  3. Decreased protein Z concentrations complicating the hypercoagulable state of Behçet's disease. Oztürk MA, et al. Clin Appl Thromb Hemost, 2003 Jul. PMID 14507116
  4. Protein Z in ischemic stroke and its etiologic subtypes. McQuillan AM, et al. Stroke, 2003 Oct. PMID 12970515
  5. Protein Z influences the prothrombotic phenotype in Factor V Leiden patients. Kemkes-Matthes B, et al. Thromb Res, 2002 May 15. PMID 12297123

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
vitamin K-dependent protein Z

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309433.1 → NP_001296362.1  vitamin K-dependent protein Z precursor

    Status: VALIDATED

    Source sequence(s)
    BC160868, JAXUCZ010000016
    UniProtKB/TrEMBL
    B1H253, G3V8K8
    Related
    ENSRNOP00000026666.8, ENSRNOT00000026666.10
    Conserved Domains (5) summary
    smart00069
    Location:27 → 89
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    cd00054
    Location:99 → 126
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00089
    Location:199 → 347
    Trypsin; Trypsin
    pfam14670
    Location:140 → 169
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl21584
    Location:199 → 404
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    83150104..83165688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017600160.3 → XP_017455649.1  vitamin K-dependent protein Z isoform X1

    UniProtKB/TrEMBL
    A0A8I6A2L4, B1H253
    Related
    ENSRNOP00000086614.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107325.1: Suppressed sequence

    Description
    NM_001107325.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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