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Ing1 inhibitor of growth family, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 306626, updated on 5-Mar-2024

Summary

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Official Symbol
Ing1provided by RGD
Official Full Name
inhibitor of growth family, member 1provided by RGD
Primary source
RGD:1306330
See related
Ensembl:ENSRNOG00000014520 AllianceGenome:RGD:1306330
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
p33ING1b; p33ING1c
Summary
Predicted to enable methylated histone binding activity. Predicted to be involved in positive regulation of transcription, DNA-templated. Predicted to act upstream of or within protein import into nucleus and regulation of cell death. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to human ING1 (inhibitor of growth family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
16q12.5
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (84639378..84649498, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (77937276..77945320, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (83277055..83278120, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 7 Neighboring gene uncharacterized LOC134482534 Neighboring gene uncharacterized LOC120097568 Neighboring gene ankyrin repeat domain 10 Neighboring gene uncharacterized LOC134482536 Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene NAD(P)HX dehydratase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of nuclear localization signal in mouse ING1 homolog protein. Ha S, et al. Biochem Biophys Res Commun, 2002 Apr 26. PMID 12054579
  2. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas. Gunduz M, et al. Cancer Res, 2000 Jun 15. PMID 10866301
  3. Tollip is a mediator of protein sumoylation. Ciarrocchi A, et al. PLoS One, 2009. PMID 19198660, Free PMC Article
  4. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, et al. Nature, 2006 Jul 6. PMID 16728974, Free PMC Article
  5. SEI family of nuclear factors regulates p53-dependent transcriptional activation. Watanabe-Fukunaga R, et al. Genes Cells, 2005 Aug. PMID 16098148

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inhibitor of growth protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038591.1 → NP_001033680.1  inhibitor of growth protein 1

    See identical proteins and their annotated locations for NP_001033680.1

    Status: PROVISIONAL

    Source sequence(s)
    AY624102
    UniProtKB/TrEMBL
    Q2TSE3
    Related
    ENSRNOP00000079627.1, ENSRNOT00000120249.1
    Conserved Domains (3) summary
    COG5034
    Location:16 → 257
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:212 → 256
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:15 → 111
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    84639378..84649498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039094601.2 → XP_038950529.1  inhibitor of growth protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZM05
    Conserved Domains (2) summary
    cd15584
    Location:329 → 373
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    cl28919
    Location:162 → 224
    ING; Inhibitor of growth (ING) domain family

  2. XM_039094602.2 → XP_038950530.1  inhibitor of growth protein 1 isoform X2

    UniProtKB/TrEMBL
    A6IWP1, G3V7V1, Q2TSE1
    Conserved Domains (2) summary
    COG5034
    Location:37 → 163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118 → 162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
Nucleotide Protein Strain
Heading Accession and Version

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