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F12 coagulation factor XII [ Rattus norvegicus (Norway rat) ]

Gene ID: 306761, updated on 6-May-2021

Summary

Official Symbol
F12provided by RGD
Official Full Name
coagulation factor XIIprovided by RGD
Primary source
RGD:1359175
See related
Ensembl:ENSRNOG00000015139
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
HAF
Expression
Restricted expression toward (RPKM 1746.7) See more
Orthologs
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Genomic context

See F12 in Genome Data Viewer
Location:
17p14
Exon count:
14
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (9207683..9215530)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9736577..9744420)

Chromosome 17 - NC_051352.1Genomic Context describing neighboring genes Neighboring gene drebrin 1 Neighboring gene proline rich 7 (synaptic) Neighboring gene G protein-coupled receptor kinase 6 Neighboring gene solute carrier family 34 member 1 Neighboring gene profilin 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in Factor XII activation IEA
Inferred from Electronic Annotation
more info
 
involved_in Factor XII activation ISO
Inferred from Sequence Orthology
more info
 
involved_in blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in blood coagulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma kallikrein-kinin cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood coagulation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of blood coagulation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibrinolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fibrinolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of plasminogen activation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of plasminogen activation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autoprocessing IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autoprocessing ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to misfolded protein IEA
Inferred from Electronic Annotation
more info
 
involved_in response to misfolded protein ISO
Inferred from Sequence Orthology
more info
 
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 
involved_in zymogen activation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in rough endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
coagulation factor XII
Names
factor XII
hageman factor
NP_001014028.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014006.1NP_001014028.1  coagulation factor XII precursor

    See identical proteins and their annotated locations for NP_001014028.1

    Status: PROVISIONAL

    Source sequence(s)
    BC088187
    UniProtKB/Swiss-Prot
    D3ZTE0
    UniProtKB/TrEMBL
    A0A0H2UI19
    Related
    ENSRNOP00000061983.2, ENSRNOT00000066586.2
    Conserved Domains (7) summary
    smart00020
    Location:361597
    Tryp_SPc; Trypsin-like serine protease
    cd00054
    Location:95130
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00061
    Location:132170
    FN1; Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces ...
    cd00062
    Location:4087
    FN2; Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and ...
    cd00190
    Location:362600
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:177207
    EGF; EGF-like domain
    pfam00051
    Location:216294
    Kringle; Kringle domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051352.1 Reference mRatBN7.2 Primary Assembly

    Range
    9207683..9215530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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