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Hist1h2bq histone cluster 1 H2B family member Q [ Rattus norvegicus (Norway rat) ]

Gene ID: 306945, updated on 11-Apr-2024

Summary

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Official Symbol
Hist1h2bqprovided by RGD
Official Full Name
histone cluster 1 H2B family member Qprovided by RGD
Primary source
RGD:1305011
See related
Ensembl:ENSRNOG00000069578 AllianceGenome:RGD:1305011
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hist1h2bh
Summary
Predicted to enable DNA binding activity and identical protein binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to other organism; and nucleosome assembly. Predicted to be located in cytosol; extracellular space; and nucleoplasm. Predicted to be part of nucleosome. Orthologous to human H2BC10 (H2B clustered histone 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 5052.9), Spleen (RPKM 3219.8) and 9 other tissues See more
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Genomic context

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Location:
17p11
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (41859955..41869889, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (41432100..41441487, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (43679925..43689311, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene histone H4C like 1 Neighboring gene homeostatic iron regulator Neighboring gene Histone cluster 1, H2an-like 1, pseudogene 2 Neighboring gene H1.6 linker histone, cluster member Neighboring gene U6 spliceosomal RNA Neighboring gene H1.4 linker histone, cluster member

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The genomic and sequence analysis of rat histone H2B genes. Choi YC, et al. DNA Seq, 1998. PMID 10524764
  2. Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Falk SJ, et al. Science, 2015 May 8. PMID 25954010, Free PMC Article
  3. Antimicrobial peptides in the first line defence of human colon mucosa. Tollin M, et al. Peptides, 2003 Apr. PMID 12860195
  4. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of chromatin IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response in mucosa ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
histone cluster 1 H2B family member Q
Names
histone 1, H2bh
histone cluster 1, H2bh
histone cluster 1, H2bq

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107352.1 → NP_001100822.1  histone cluster 1 H2B family member Q

    See identical proteins and their annotated locations for NP_001100822.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474064
    UniProtKB/TrEMBL
    A0A8I6AGQ8, A6KLP6, A6KNB9, G3V8B3, G3V9C7
    Related
    ENSRNOP00000083018.1, ENSRNOT00000116857.1
    Conserved Domains (1) summary
    smart00427
    Location:28 → 124
    H2B; Histone H2B

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    41859955..41869889 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276432.1 → XP_063132502.1  histone cluster 1 H2B family member Q isoform X1

    UniProtKB/TrEMBL
    A6KLP6, G3V8B3, G3V9C7

  2. XM_063276433.1 → XP_063132503.1  histone cluster 1 H2B family member Q isoform X1

    UniProtKB/TrEMBL
    A6KLP6, G3V8B3, G3V9C7

RNA

  1. XR_010058867.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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