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Akr1e2 aldo-keto reductase family 1, member E2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307091, updated on 11-Apr-2024

Summary

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Official Symbol
Akr1e2provided by RGD
Official Full Name
aldo-keto reductase family 1, member E2provided by RGD
Primary source
RGD:1309599
See related
Ensembl:ENSRNOG00000017165 AllianceGenome:RGD:1309599
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Akr1e1; Akr1cl2
Summary
Predicted to enable alditol:NADP+ 1-oxidoreductase activity. Predicted to be active in cytosol. Orthologous to human AKR1E2 (aldo-keto reductase family 1 member E2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 323.0), Kidney (RPKM 248.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Akr1e2 in Genome Data Viewer
Location:
17q12.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (70645835..70660366)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (65735909..65750441)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (69365437..69379944)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC108348616 Neighboring gene serine and arginine rich splicing factor 3, pseudogene 9 Neighboring gene aldo-keto reductase family 1, member C2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of htAKR, a novel gene product in the aldo-keto reductase family specifically expressed in human testis. Azuma Y, et al. Mol Hum Reprod, 2004 Jul. PMID 15118078
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105536

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1,5-anhydro-D-fructose reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
1,5-anhydro-D-fructose reductase
Names
AF reductase
aldo-keto reductase family 1 member C-like protein 2
aldo-keto reductase family 1, member C-like 2
aldo-keto reductase family 1, member E1
NP_001008343.1
XP_008770087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008342.1 → NP_001008343.1  1,5-anhydro-D-fructose reductase

    See identical proteins and their annotated locations for NP_001008343.1

    Status: PROVISIONAL

    Source sequence(s)
    BC086397
    UniProtKB/Swiss-Prot
    Q5U1Y4
    UniProtKB/TrEMBL
    A0A8I6GF05
    Related
    ENSRNOP00000023133.5, ENSRNOT00000023133.8
    Conserved Domains (2) summary
    COG0656
    Location:4 → 282
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:4 → 287
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    70645835..70660366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771865.3 → XP_008770087.1  1,5-anhydro-D-fructose reductase isoform X1

    UniProtKB/TrEMBL
    A0A8I6GF05
    Conserved Domains (2) summary
    COG0656
    Location:4 → 243
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:4 → 248
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U1Y4.1 GenPept UniProtKB/Swiss-Prot:Q5U1Y4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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