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Cndp1 carnosine dipeptidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307212, updated on 13-Apr-2024

Summary

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Official Symbol
Cndp1provided by RGD
Official Full Name
carnosine dipeptidase 1provided by RGD
Primary source
RGD:1359493
See related
Ensembl:ENSRNOG00000027739 AllianceGenome:RGD:1359493
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable dipeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within regulation of cellular protein metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human CNDP1 (carnosine dipeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 74.0), Uterus (RPKM 31.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18q12.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (80254499..80305845, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (77984886..78030837, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (81466717..81512841, complement)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482989 Neighboring gene zinc finger protein 407 Neighboring gene carnosine dipeptidase 2 Neighboring gene divergent protein kinase domain 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Association of variants in the carnosine peptidase 1 gene (CNDP1) with diabetic nephropathy in American Indians. Chakkera HA, et al. Mol Genet Metab, 2011 Jun. PMID 21393041, Free PMC Article
  2. Is carnosinase 1 gene (CNDP1) polymorphism associated with chronic kidney disease progression in children and young adults? results of a family-based study. Kiliś-Pstrusińska K, et al. Arch Med Res, 2010 Jul. PMID 20851293
  3. Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. Teufel M, et al. J Biol Chem, 2003 Feb 21. PMID 12473676
  4. Metabolite proofreading in carnosine and homocarnosine synthesis: molecular identification of PM20D2 as β-alanyl-lysine dipeptidase. Veiga-da-Cunha M, et al. J Biol Chem, 2014 Jul 11. PMID 24891507, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC93742

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallodipeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-Ala-His dipeptidase
Names
CNDP dipeptidase 1
carnosine dipeptidase 1 (metallopeptidase M20 family)
NP_001007688.1
XP_008770357.1
XP_038952698.1
XP_063133361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007687.2 → NP_001007688.1  beta-Ala-His dipeptidase

    See identical proteins and their annotated locations for NP_001007688.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q66HG3
    Related
    ENSRNOP00000034652.3, ENSRNOT00000034970.6
    Conserved Domains (2) summary
    PRK08201
    Location:16 → 481
    PRK08201; hypothetical protein; Provisional
    cd05676
    Location:13 → 481
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    80254499..80305845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277291.1 → XP_063133361.1  beta-Ala-His dipeptidase isoform X2

  2. XM_039096770.2 → XP_038952698.1  beta-Ala-His dipeptidase isoform X3

    Conserved Domains (1) summary
    cd05676
    Location:13 → 426
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase

  3. XM_008772135.4 → XP_008770357.1  beta-Ala-His dipeptidase isoform X1

    See identical proteins and their annotated locations for XP_008770357.1

    UniProtKB/Swiss-Prot
    Q66HG3
    Conserved Domains (2) summary
    PRK08201
    Location:16 → 481
    PRK08201; hypothetical protein; Provisional
    cd05676
    Location:13 → 481
    M20_dipept_like_CNDP; M20 cytosolic nonspecific dipeptidases including anserinase and serum carnosinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66HG3.1 GenPept UniProtKB/Swiss-Prot:Q66HG3

Gene LinkOut

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