Arsi arylsulfatase family, member I [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arsiprovided by RGD
Official Full Name: arylsulfatase family, member Iprovided by RGD
Primary source: RGD:1310242
See related: Ensembl:ENSRNOG00000026060 AllianceGenome:RGD:1310242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310242
Summary: Predicted to enable metal ion binding activity and sulfuric ester hydrolase activity. Predicted to be located in endoplasmic reticulum and extracellular region. Orthologous to human ARSI (arylsulfatase family member I). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 38.2), Muscle (RPKM 15.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (56634556..56642168)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (54364160..54371772)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (56180089..56186068)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sulfuric ester hydrolase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arylsulfatase I

Names: ASI

NP_001041346.1

EC 3.1.6.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047881.2 → NP_001041346.1 arylsulfatase I precursor

See identical proteins and their annotated locations for NP_001041346.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

Q32KJ8

UniProtKB/TrEMBL

A6IXE7

Related

ENSRNOP00000033542.4, ENSRNOT00000030966.5

Conserved Domains (2) summary

COG3119
Location:49 → 485

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

cd16029
Location:48 → 478

4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B