Rbm22 RNA binding motif protein 22 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbm22provided by RGD
Official Full Name: RNA binding motif protein 22provided by RGD
Primary source: RGD:1305770
See related: Ensembl:ENSRNOG00000019235 AllianceGenome:RGD:1305770
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable U6 snRNA binding activity; calcium-dependent protein binding activity; and pre-mRNA binding activity. Predicted to be involved in several processes, including mRNA cis splicing, via spliceosome; positive regulation of RNA splicing; and positive regulation of nucleocytoplasmic transport. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Prp19 complex; U2-type catalytic step 1 spliceosome; and U2-type catalytic step 2 spliceosome. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 132.6), Spleen (RPKM 109.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (56283807..56294615)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (54013374..54024182)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (55828158..55839421)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables U6 snRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U6 snRNA binding	ISO Inferred from Sequence Orthology more info
enables U6 snRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables pre-mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA binding	ISO Inferred from Sequence Orthology more info
enables pre-mRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to xenobiotic stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA cis splicing, via spliceosome	ISO Inferred from Sequence Orthology more info
involved_in mRNA cis splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of RNA splicing	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Prp19 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 1 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of U2-type catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
part_of catalytic step 2 spliceosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pre-mRNA-splicing factor RBM22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025676.1 → NP_001020847.1 pre-mRNA-splicing factor RBM22

See identical proteins and their annotated locations for NP_001020847.1

Status: PROVISIONAL

Source sequence(s)

BC097991

UniProtKB/Swiss-Prot

Q4V7D7

UniProtKB/TrEMBL

A0A8I5ZWV1

Related

ENSRNOP00000026087.2, ENSRNOT00000026087.4

Conserved Domains (2) summary

smart00356
Location:159 → 185

ZnF_C3H1; zinc finger

cd12224
Location:231 → 304

RRM_RBM22; RNA recognition motif (RRM) found in Pre-mRNA-splicing factor RBM22 and similar proteins