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Csnk2a2 casein kinase 2 alpha 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307641, updated on 11-Apr-2024

Summary

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Official Symbol
Csnk2a2provided by RGD
Official Full Name
casein kinase 2 alpha 2provided by RGD
Primary source
RGD:1306882
See related
AllianceGenome:RGD:1306882
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein N-terminus binding activity and protein serine/threonine kinase activity. Involved in cerebral cortex development; liver regeneration; and spermatogenesis. Located in several cellular components, including acrosomal vesicle; chromatin; and nucleus. Orthologous to human CSNK2A2 (casein kinase 2 alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 73.2), Thymus (RPKM 73.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p13
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (9562340..9602136)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (9556443..9596080)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (9972537..10012043)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098510 Neighboring gene serine protease 54 Neighboring gene coiled-coil domain containing 113 Neighboring gene cilia and flagella associated protein 20 Neighboring gene matrix metallopeptidase 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein kinase CK2alpha' is induced by serum as a delayed early gene and cooperates with Ha-ras in fibroblast transformation. Orlandini M, et al. J Biol Chem, 1998 Aug 14. PMID 9694889
  2. Differential localization of alpha' and beta subunits of protein kinase CK2 during rat spermatogenesis. Alvarado-Díaz CP, et al. Cell Tissue Res, 2009 Oct. PMID 19711102
  3. The TRAIL to selective tumor death. French LE, et al. Nat Med, 1999 Feb. PMID 9930856
  4. Role of autophosphorylation in regulation of protein kinase CK2 from rat neuronal chromatin. Kulikova OG, et al. Biochemistry (Mosc), 1998 Dec. PMID 9916157
  5. The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory beta-subunit. Sarrouilhe D, et al. Biochim Biophys Acta, 1998 Jun 22. PMID 9630630

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cerebral cortex development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in double-strand break repair ISO
Inferred from Sequence Orthology
more info
  
involved_in liver regeneration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in negative regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromosome separation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromosome separation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in spermatogenesis IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase II subunit alpha'
Names
casein kinase 2, alpha prime polypeptide
casein kinase II, alpha 2, polypeptide
NP_001100879.1
XP_038953618.1
XP_038953619.1
XP_038953620.1
XP_038953621.1
XP_038953622.1
XP_038953623.1
XP_063134049.1
XP_063134050.1
XP_063134051.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107409.1 → NP_001100879.1  casein kinase II subunit alpha'

    See identical proteins and their annotated locations for NP_001100879.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474006
    UniProtKB/TrEMBL
    A6JY05, B4F7A9
    Conserved Domains (2) summary
    cd14132
    Location:22 → 326
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
    pfam00069
    Location:40 → 325
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    9562340..9602136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097690.2 → XP_038953618.1  casein kinase II subunit alpha' isoform X1

    UniProtKB/TrEMBL
    B4F7A9
    Conserved Domains (1) summary
    cd14132
    Location:22 → 309
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  2. XM_039097692.2 → XP_038953620.1  casein kinase II subunit alpha' isoform X3

    UniProtKB/TrEMBL
    B4F7A9
    Conserved Domains (1) summary
    cd14132
    Location:22 → 281
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  3. XM_039097694.2 → XP_038953622.1  casein kinase II subunit alpha' isoform X6

    Conserved Domains (1) summary
    cd14132
    Location:22 → 247
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  4. XM_063277980.1 → XP_063134050.1  casein kinase II subunit alpha' isoform X5

  5. XM_063277979.1 → XP_063134049.1  casein kinase II subunit alpha' isoform X5

  6. XM_039097691.2 → XP_038953619.1  casein kinase II subunit alpha' isoform X2

    UniProtKB/TrEMBL
    B4F7A9
    Conserved Domains (1) summary
    cd14132
    Location:22 → 298
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  7. XM_039097693.2 → XP_038953621.1  casein kinase II subunit alpha' isoform X4

    UniProtKB/TrEMBL
    B4F7A9
    Conserved Domains (1) summary
    cd14132
    Location:22 → 275
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2

  8. XM_063277981.1 → XP_063134051.1  casein kinase II subunit alpha' isoform X5

  9. XM_039097695.2 → XP_038953623.1  casein kinase II subunit alpha' isoform X5

    Conserved Domains (1) summary
    cd14132
    Location:1 → 189
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
Nucleotide Protein Strain
Heading Accession and Version

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