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Tent4b terminal nucleotidyltransferase 4B [ Rattus norvegicus (Norway rat) ]

Gene ID: 307745, updated on 11-Apr-2024

Summary

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Official Symbol
Tent4bprovided by RGD
Official Full Name
terminal nucleotidyltransferase 4Bprovided by RGD
Primary source
RGD:1309587
See related
Ensembl:ENSRNOG00000024212 AllianceGenome:RGD:1309587
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Papd5
Summary
Predicted to enable guanylyltransferase activity and polynucleotide adenylyltransferase activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of mRNA stability. Predicted to be located in cytoplasm. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Orthologous to human TENT4B (terminal nucleotidyltransferase 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 113.0), Heart (RPKM 112.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p11
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (34984244..35042423, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (18807616..18868969, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (19771289..19834759, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098503 Neighboring gene bromodomain containing 7 Neighboring gene adenylate cyclase 7 Neighboring gene uncharacterized LOC134483299 Neighboring gene HEAT repeat containing 3 Neighboring gene uncharacterized LOC134483300 Neighboring gene uncharacterized LOC108348906 Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation. Lim J, et al. Science, 2018 Aug 17. PMID 30026317
  2. Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism. Shin J, et al. Nucleic Acids Res, 2017 Jun 20. PMID 28383716, Free PMC Article
  3. Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. Berndt H, et al. RNA, 2012 May. PMID 22442037, Free PMC Article
  4. Interaction profiling identifies the human nuclear exosome targeting complex. Lubas M, et al. Mol Cell, 2011 Aug 19. PMID 21855801
  5. PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease. Boele J, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049417, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables guanylyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables poly(A) RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) RNA polymerase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA 3' uridylation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carbohydrate homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in histone mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in miRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
involved_in poly(A)-dependent snoRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in polyadenylation-dependent ncRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in polyadenylation-dependent ncRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of TRAMP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAMP complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
terminal nucleotidyltransferase 4B
Names
PAP associated domain containing 5
PAP-associated domain-containing protein 5
non-canonical poly(A) RNA polymerase PAPD5
poly(A) RNA polymerase D5, non-canonical
NP_001100886.2
NP_001388155.1
NP_001401942.1
NP_001401944.1
XP_038953651.1
XP_038953652.1
XP_063134086.1
XP_063134087.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107416.2 → NP_001100886.2  terminal nucleotidyltransferase 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

  2. NM_001401226.1 → NP_001388155.1  terminal nucleotidyltransferase 4B isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    Related
    ENSRNOP00000095048.1, ENSRNOT00000116618.1

  3. NM_001415013.2 → NP_001401942.1  terminal nucleotidyltransferase 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

  4. NM_001415015.2 → NP_001401944.1  terminal nucleotidyltransferase 4B isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    34984244..35042423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039097724.2 → XP_038953652.1  terminal nucleotidyltransferase 4B isoform X1

    UniProtKB/TrEMBL
    A0A0G2K239, A0A8I6G9A0
    Related
    ENSRNOP00000083622.1
    Conserved Domains (1) summary
    COG5260
    Location:134 → 455
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  2. XM_039097723.2 → XP_038953651.1  terminal nucleotidyltransferase 4B isoform X1

    UniProtKB/TrEMBL
    A0A0G2K239, A0A8I6G9A0
    Conserved Domains (1) summary
    COG5260
    Location:134 → 455
    TRF4; DNA polymerase sigma [Replication, recombination and repair]

  3. XM_063278016.1 → XP_063134086.1  terminal nucleotidyltransferase 4B isoform X2

  4. XM_063278017.1 → XP_063134087.1  terminal nucleotidyltransferase 4B isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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